The development of interventions to slow or halt the progression of Parkinson's disease
remains a priority for patients and researchers alike. To date, no agents have been shown to …

Most neurodegenerative disorders are diseases of protein homeostasis, with misfolded
aggregates accumulating. The neurodegenerative process is mediated by numerous …

Bile acids are best known as detergents involved in the digestion of lipids. In addition, new
data in the last decade have shown that bile acids also function as gut hormones capable of …

Tauroursodeoxycholic acid (TUDCA) is a naturally occurring hydrophilic bile acid that has
been used for centuries in Chinese medicine. Chemically, TUDCA is a taurine conjugate of …

Progress toward the development of efficacious therapies for Alzheimer's disease (AD) is
halted by a lack of understanding early underlying pathological mechanisms. Systems …

Irrespective of the morphological features of end-stage cell death (that may be apoptotic,
necrotic, autophagic, or mitotic), mitochondrial membrane permeabilization (MMP) is …

Stress induced by accumulation of unfolded proteins at the endoplasmic reticulum (ER) is a
classic feature of secretory cells and is observed in many tissues in human diseases …

Diseases that affect the eye, including photoreceptor degeneration, diabetic retinopathy, and
glaucoma, affect 11.8 million people in the US, resulting in vision loss and blindness. Loss of …

Bile acids are signalling hormones involved in the regulation of several metabolic pathways.
The ability of bile acids to bind and signal through their receptors is modulated by the gut …

An expanded CAG repeat is the underlying genetic defect in Huntington disease, a disorder
characterized by motor, psychiatric and cognitive deficits and striatal atrophy associated with …