Genetics of circadian rhythms and sleep in human health and disease
Circadian rhythms and sleep are fundamental biological processes integral to human
health. Their disruption is associated with detrimental physiological consequences …
health. Their disruption is associated with detrimental physiological consequences …
Insomnia disorder: State of the science and challenges for the future
D Riemann, F Benz, RJ Dressle… - Journal of sleep …, 2022 - Wiley Online Library
Insomnia disorder comprises symptoms during night and day that strongly affect quality of
life and wellbeing. Prolonged sleep latency, difficulties to maintain sleep and early morning …
life and wellbeing. Prolonged sleep latency, difficulties to maintain sleep and early morning …
Safety and efficacy of daridorexant in patients with insomnia disorder: results from two multicentre, randomised, double-blind, placebo-controlled, phase 3 trials
Background Daytime functioning is impaired in people with insomnia disorder. Currently
available dual orexin receptor antagonists have shown efficacy in insomnia disorder, but do …
available dual orexin receptor antagonists have shown efficacy in insomnia disorder, but do …
Brain mechanisms of insomnia: new perspectives on causes and consequences
EJW Van Someren - Physiological reviews, 2021 - journals.physiology.org
While insomnia is the second most common mental disorder, progress in our understanding
of underlying neurobiological mechanisms has been limited. The present review addresses …
of underlying neurobiological mechanisms has been limited. The present review addresses …
Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use
Tobacco and alcohol use are leading causes of mortality that influence risk for many
complex diseases and disorders. They are heritable, and etiologically related, behaviors that …
complex diseases and disorders. They are heritable, and etiologically related, behaviors that …
Sleep, insomnia, and depression
Since ancient times it is known that melancholia and sleep disturbances co-occur. The
introduction of polysomnography into psychiatric research confirmed a disturbance of sleep …
introduction of polysomnography into psychiatric research confirmed a disturbance of sleep …
Sleep and circadian rhythm in response to the COVID-19 pandemic
This commentary highlights the critical role of sleep as a public health issue, particularly
during a stressful life period such as the COVID-19 pandemic, and provides evidence-based …
during a stressful life period such as the COVID-19 pandemic, and provides evidence-based …
Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways
Insomnia is the second most prevalent mental disorder, with no sufficient treatment
available. Despite substantial heritability, insight into the associated genes and …
available. Despite substantial heritability, insight into the associated genes and …
Sleep health: an opportunity for public health to address health equity
The concept of sleep health provides a positive holistic framing of multiple sleep
characteristics, including sleep duration, continuity, timing, alertness, and satisfaction. Sleep …
characteristics, including sleep duration, continuity, timing, alertness, and satisfaction. Sleep …
The gut microbiota-bile acid axis links the positive association between chronic insomnia and cardiometabolic diseases
Z Jiang, L Zhuo, Y He, Y Fu, L Shen, F Xu… - Nature …, 2022 - nature.com
Evidence from human cohorts indicates that chronic insomnia is associated with higher risk
of cardiometabolic diseases (CMD), yet whether gut microbiota plays a role is unclear. Here …
of cardiometabolic diseases (CMD), yet whether gut microbiota plays a role is unclear. Here …