The genetic landscape of Parkinson's disease (PD) is characterised by rare high penetrance
pathogenic variants causing familial disease, genetic risk factor variants driving PD risk in a …

Mitochondria are central hubs of cellular metabolism and are tightly connected to signaling
pathways. The dynamic plasticity of mitochondria to fuse, divide, and contact other …

Understanding the mechanisms governing selective turnover of mutation-bearing mtDNA is
fundamental to design therapeutic strategies against mtDNA diseases. Here, we show that …

As the population ages, the incidence of neurodegenerative diseases is increasing. Due to
intensive research, important steps in the elucidation of pathogenetic cascades have been …

Point mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of
familial Parkinson's disease (PD) and are implicated in a significant proportion of apparently …

Mitochondrial health is based on a delicate balance of specific mitochondrial functions (eg
metabolism, signaling, dynamics) that are impaired in neurodegenerative diseases …

Parkinson disease (PD) is a neurodegenerative disorder marked by the preferential
dysfunction and death of dopaminergic neurons in the substantia nigra. The onset and …

Background Mitochondrial dysfunction plays a prominent role in the pathogenesis of
Parkinson's disease (PD), and several genes linked to familial PD, including PINK1 …

Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects around
2% of individuals over 60 years old. It is characterised by the loss of dopaminergic neurons …

Parkinson's disease (PD) is the second most common neurodegenerative disorder in the
aging population, and no disease-modifying therapy has been approved to date. The …