Force generation in striated muscle is primarily controlled by structural changes in the actin-
containing thin filaments triggered by an increase in intracellular calcium concentration …

Muscular contraction is a fundamental phenomenon in all animals; without it life as we know
it would be impossible. The basic mechanism in muscle, including heart muscle, involves …

The thick filament is a key component of sarcomeres, the basic units of striated muscle.
Alterations in thick filament proteins are associated with familial hypertrophic …

Pumping of the heart is powered by filaments of the motor protein myosin that pull on actin
filaments to generate cardiac contraction. In addition to myosin, the filaments contain cardiac …

The heart is an extraordinarily versatile pump, finely tuned to respond to a multitude of
demands. Given the heart pumps without rest for decades its efficiency is particularly …

The discovery of the giant protein titin, also known as connectin, dates almost half a century
back. In this review, I recapitulate major advances in the discovery of the titin filaments and …

The sarcomere is the smallest functional unit of muscle contraction. It is delineated by a
protein-rich structure known as the Z-disk, alternating with M-bands. The Z-disk anchors the …

Mutations in atrial-enriched genes can cause a primary atrial myopathy that can contribute to
overall cardiovascular dysfunction. MYBPHL encodes myosin-binding protein H-like (MyBP …

Titin is a molecular spring in parallel with myosin motors in each muscle half-sarcomere,
responsible for passive force development at sarcomere length (SL) above the physiological …

Hypertrophic cardiomyopathy (HCM), a disease characterized by cardiac muscle
hypertrophy and hypercontractility, is the most frequently inherited disorder of the heart …