Sleep is universal, tightly regulated, and its loss impairs cognition. But why does the brain
need to disconnect from the environment for hours every day? The synaptic homeostasis …

According to Alzheimer's Disease International, 55 million people worldwide are living with
dementia. Dementia is a disorder that manifests as a set of related symptoms, which usually …

It is hypothesized that deep sleep is essential for restoring the brain's capacity to learn
efficiently, especially in regions heavily activated during the day. However, causal evidence …

Parkinson's disease (PD) is a progressive neurodegenerative disorder. The classical
behavioral defects of PD patients involve motor symptoms such as bradykinesia, tremor, and …

Major depressive disorder is a debilitating condition with a lifetime risk of ten percent. Most
treatments take several weeks to achieve clinical efficacy, limiting the ability to bring instant …

Sleep is widely believed to play an essential role in synaptic plasticity. However, the precise
mechanisms governing this presumptive function are largely unknown. There is also …

Sleep must serve an essential, universal function, one that offsets the risk of being
disconnected from the environment. The synaptic homeostasis hypothesis (SHY) is an …

Sleep deprivation (SD) is the most widely documented rapid-onset antidepressant therapy,
targeting the broadly defined depressive syndrome. Although SD responses are transient, its …

As we age, sleep patterns undergo significant modifications in micro and macrostructure,
worsening cognition and quality of life. These are associated with remarkable brain …

Concussion after a force to the head is called mild traumatic brain injury (mTBI).
Approximately 1 in 5 patients with mTBI will develop chronic pain (headache and …