Vancomycin use is often associated with nephrotoxicity. It remains uncertain, however, to
what extent vancomycin is directly responsible, as numerous potential risk factors for acute …

Objectives: The objective of this systematic review and meta-analysis was to assess acute
kidney injury with combination therapy of vancomycin plus piperacillin-tazobactam, in …

Background: Recent studies have identified the combination of vancomycin with piperacillin-
tazobactam (VPT) to be associated with increased nephrotoxicity. Multiple, large cohort …

Background. Recent evidence suggests that among patients receiving vancomycin, receipt
of concomitant piperacillin–tazobactam increases the risk of nephrotoxicity. Well-controlled …

Background Acute kidney injury is a major complication of vancomycin treatment, especially
when it is co-administered with other nephrotoxins. Objectives This meta-analysis aims to …

Recent reports have demonstrated that vancomycin (VAN) may lead to an increase in the
incidence of acute kidney injury (AKI) when it is combined with antipseudomonal beta …

Introduction: β-lactams have been consistently associated with the majority of drug-related
adverse events. Generally, these are mild under proper dosing and judicious selection …

Study Objective To evaluate the association of the development of acute kidney injury (AKI)
when piperacillin‐tazobactam is used in combination with vancomycin compared with …

Abstract Background Nephrotoxins contribute to 20%–40% of acute kidney injury (AKI)
cases in the intensive care unit (ICU). The combination of piperacillin-tazobactam (PTZ) and …

Background: Patients often receive broad-spectrum antibiotics for nosocomial infections
commonly with activity against Pseudomonas aeruginosa and methicillin-resistant …