[HTML][HTML] Ischemia-triggered glutamate excitotoxicity from the perspective of glial cells
D Belov Kirdajova, J Kriska, J Tureckova… - Frontiers in cellular …, 2020 - frontiersin.org
A plethora of neurological disorders shares a final common deadly pathway known as
excitotoxicity. Among these disorders, ischemic injury is a prominent cause of death and …
excitotoxicity. Among these disorders, ischemic injury is a prominent cause of death and …
The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention
AL Sheldon, MB Robinson - Neurochemistry international, 2007 - Elsevier
Extracellular concentrations of the predominant excitatory neurotransmitter, glutamate, and
related excitatory amino acids are maintained at relatively low levels to ensure an …
related excitatory amino acids are maintained at relatively low levels to ensure an …
[HTML][HTML] Excitatory amino acid transporters in physiology and disorders of the central nervous system
AR Malik, TE Willnow - International journal of molecular sciences, 2019 - mdpi.com
Excitatory amino acid transporters (EAATs) encompass a class of five transporters with
distinct expression in neurons and glia of the central nervous system (CNS). EAATs are …
distinct expression in neurons and glia of the central nervous system (CNS). EAATs are …
Astrocytes: targets for neuroprotection in stroke
In the past two decades, over 1000 clinical trials have failed to demonstrate a benefit in
treating stroke, with the exception of thrombolytics. Although many targets have been …
treating stroke, with the exception of thrombolytics. Although many targets have been …
Selective dysfunction of hippocampal CA1 astrocytes contributes to delayed neuronal damage after transient forebrain ischemia
YB Ouyang, LA Voloboueva, LJ Xu… - Journal of …, 2007 - Soc Neuroscience
Transient global ischemia, as with cardiac arrest, causes loss of CA1 hippocampal neurons
2–4 d later, whereas nearby dentate gyrus (DG) neurons are relatively resistant. Whether …
2–4 d later, whereas nearby dentate gyrus (DG) neurons are relatively resistant. Whether …
[HTML][HTML] Overview of glutamatergic dysregulation in central pathologies
As the major excitatory neurotransmitter in the mammalian central nervous system,
glutamate plays a key role in many central pathologies, including gliomas, psychiatric …
glutamate plays a key role in many central pathologies, including gliomas, psychiatric …
Molecular and cellular physiology of sodium-dependent glutamate transporters
Glutamate is the major excitatory transmitter in the vertebrate brain. After its release from
presynaptic nerve terminals, it is rapidly taken up by high-affinity sodium-dependent plasma …
presynaptic nerve terminals, it is rapidly taken up by high-affinity sodium-dependent plasma …
Regulation and dysregulation of glutamate transporters
R Sattler, JD Rothstein - Neurotransmitter Transporters, 2006 - Springer
Glutamate is the primary excitatory neurotransmitter in the central nervous system. During
synaptic activity, glutamate is released into the synaptic cleft and binds to glutamate …
synaptic activity, glutamate is released into the synaptic cleft and binds to glutamate …
GLT-1 transporter: an effective pharmacological target for various neurological disorders
Abstract l-Glutamate is the predominant excitatory neurotransmitter in the central nervous
system (CNS) and is directly and indirectly involved in a variety of brain functions. Glutamate …
system (CNS) and is directly and indirectly involved in a variety of brain functions. Glutamate …
Up-regulation of brain-enriched miR-107 promotes excitatory neurotoxicity through down-regulation of glutamate transporter-1 expression following ischaemic stroke
ZB Yang, Z Zhang, TB Li, Z Lou, SY Li, H Yang… - Clinical …, 2014 - portlandpress.com
Recent studies have uncovered that accumulation of glutamate after ischaemic stroke is
closely associated with the down-regulation of glutamate transporter-1 (GLT-1) expression …
closely associated with the down-regulation of glutamate transporter-1 (GLT-1) expression …