A plethora of neurological disorders shares a final common deadly pathway known as
excitotoxicity. Among these disorders, ischemic injury is a prominent cause of death and …

Extracellular concentrations of the predominant excitatory neurotransmitter, glutamate, and
related excitatory amino acids are maintained at relatively low levels to ensure an …

Excitatory amino acid transporters (EAATs) encompass a class of five transporters with
distinct expression in neurons and glia of the central nervous system (CNS). EAATs are …

In the past two decades, over 1000 clinical trials have failed to demonstrate a benefit in
treating stroke, with the exception of thrombolytics. Although many targets have been …

Transient global ischemia, as with cardiac arrest, causes loss of CA1 hippocampal neurons
2–4 d later, whereas nearby dentate gyrus (DG) neurons are relatively resistant. Whether …

As the major excitatory neurotransmitter in the mammalian central nervous system,
glutamate plays a key role in many central pathologies, including gliomas, psychiatric …

Glutamate is the major excitatory transmitter in the vertebrate brain. After its release from
presynaptic nerve terminals, it is rapidly taken up by high-affinity sodium-dependent plasma …

Glutamate is the primary excitatory neurotransmitter in the central nervous system. During
synaptic activity, glutamate is released into the synaptic cleft and binds to glutamate …

Abstract l-Glutamate is the predominant excitatory neurotransmitter in the central nervous
system (CNS) and is directly and indirectly involved in a variety of brain functions. Glutamate …

Recent studies have uncovered that accumulation of glutamate after ischaemic stroke is
closely associated with the down-regulation of glutamate transporter-1 (GLT-1) expression …