Abstract Assay of Transposase Accessible Chromatin sequencing (ATAC-seq) is widely
used in studying chromatin biology, but a comprehensive review of the analysis tools has …

Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is a central method in
epigenomic research. Genome-wide analysis of histone modifications, such as enhancer …

We present HiGlass, an open source visualization tool built on web technologies that
provides a rich interface for rapid, multiplex, and multiscale navigation of 2D genomic maps …

The molecular mechanisms underlying folding of mammalian chromosomes remain poorly
understood. The transcription factor CTCF is a candidate regulator of chromosomal …

RNA modification is a dynamic and reversible process regulated by a series of writers,
erasers and readers (WERs). Abnormal changes of WERs will disrupt the RNA modification …

Background CUT&RUN is an efficient epigenome profiling method that identifies sites of
DNA binding protein enrichment genome-wide with high signal to noise and low sequencing …

An intricate molecular machinery is at the core of gene expression regulation in every cell.
During the initial stages of organismal development, the coordinated activation of diverse …

Transcriptional regulation is a fundamental molecular mechanism involved in almost every
aspect of life, from homeostasis to development, from metabolism to behavior, from reaction …

Technological advances enabling massively parallel measurement of biological features—
such as microarrays, high-throughput sequencing and mass spectrometry—have ushered in …

Abstract Background The domestic sheep (Ovis aries) is an important agricultural species
raised for meat, wool, and milk across the world. A high-quality reference genome for this …