The role of neurotrophins as regulatory factors that mediate the differentiation and survival of
neurons has been well described. More recent evidence indicates that neurotrophins may …

TRH is a tripeptide amide that functions as a neurotransmitter but also serves as a
neurohormone that has a critical role in the central regulation of the hypothalamic-pituitary …

Brain-derived neurotrophic factor (BDNF) is a small dimeric protein, structurally related to
nerve growth factor, which is abundantly and widely expressed in the adult mammalian …

The neurotrophins are growth factors that play critical roles in the development,
maintenance, survival, and death of the nervous system. The signal transducing systems …

The proteins of the mammalian neurotrophin family (nerve growth factor (NGF), brain-
derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5)) …

purpose. To determine whether acute experimental glaucoma in rats obstructs retrograde
transport of brain-derived neurotrophic factor (BDNF) to retinal ganglion cells (RGCs) …

purpose. In both animal model systems and in human glaucoma, retinal ganglion cells
(RGCs) die by apoptosis. To understand how RGC apoptosis is initiated in these systems …

The Trk family of receptors play a wide variety of roles in physiological and disease
processes in both neuronal and non-neuronal tissues. Amongst these the TrkB receptor in …

purpose. To develop a modified adenoassociated viral (AAV) vector capable of efficient
transfection of retinal ganglion cells (RGCs) and to test the hypothesis that use of this vector …

Profound and early basal forebrain cholinergic neuron (BFCN) degeneration is a hallmark of
Alzheimer's disease (AD). Loss of synapses between basal forebrain and hippocampal and …