An equilibrium needs to be established by the cellular and acellular components of the
ovarian follicle if developmental competence is to be acquired by the oocyte. Both cumulus …

BACKGROUND Initially identified for their capability to induce heterotopic bone formation,
bone morphogenetic proteins (BMPs) are multifunctional growth factors that belong to the …

Two major functions of the mammalian ovary are the production of germ cells (oocytes),
which allow continuation of the species, and the generation of bioactive molecules, primarily …

BACKGROUND Polycystic ovary syndrome (PCOS) is a common metabolic dysfunction and
heterogeneous endocrine disorder in women of reproductive age. Although patients with …

Context: Human follicular fluid is a combination of proteins, metabolites, and ionic
compounds that is indicative of the general state of follicular metabolism and is associated …

The assessment of oocyte quality in human in vitro fertilization (IVF) is getting increasing
attention from embryologists. Oocyte selection and the identification of the best oocytes, in …

Understanding the physiology underlying the complex dialog between the oocyte and its
surrounding somatic cells within the ovarian follicle has been crucial in defining optimal …

BACKGROUND A large number of studies have contributed to understanding the general
mechanisms driving ovarian folliculogenesis in humans and show a complex endocrine …

It is well established that age-related decline of the biological capacity of a woman to
reproduce is primarily related to the poor developmental potential of her gametes. This …

Cytokines are key regulators of ovarian physiology, particularly in relation to folliculogenesis
and ovulation, where they contribute to creating an environment supporting follicle selection …