Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels widely
expressed in the central nervous system that play key roles in excitatory synaptic …

Rationale l-Glutamate is the major excitatory neurotransmitter in the central nervous system
(CNS) and mediates its actions via activation of both ionotropic and metabotropic receptor …

N‐methyl‐D‐aspartate receptors (NMDARs) are ion channels gated by glutamate, the major
excitatory neurotransmitter in the mammalian central nervous system (CNS). They are …

Abstract l-glutamate is an excitatory neurotransmitter in the central nervous system (CNS),
which can activate ionotropic receptors (iGluRs) and metabotropic (mGluRs) receptors. N …

N-methyl-d-aspartate receptors (NMDARs) are glutamate-gated ion channels that play key
roles in brain physiology and pathology. Because numerous pathologic conditions involve …

Pain is the major reason patients seek medical care. The treatment of pain, particularly
chronic pain associated with cancer and damage to the nervous system, is at present …

Ionotropic glutamate receptors (iGluRs) mediate excitatory neurotransmission within the
mammalian central nervous system. iGluRs exist as three main groups: N-methyl-d …

N-methyl-d-aspartate (NMDA) receptors are ionotropic glutamate receptors that mediate
excitatory neurotransmission. NMDA receptors are also important drug targets that are …