Principles of diffusion kurtosis imaging and its role in early diagnosis of neurodegenerative disorders

A Arab, A Wojna-Pelczar, A Khairnar, N Szabó… - Brain research …, 2018 - Elsevier
Pathology of neurodegenerative diseases can be correlated with intra-neuronal as well as
extracellular changes which lead to neuronal degeneration. The central nervous system …

[HTML][HTML] An introduction to kurtosis fractional anisotropy

B Hansen - AJNR: American Journal of Neuroradiology, 2019 - ncbi.nlm.nih.gov
Neuroradiology and imaging-based diagnostics in general have a dire need for scan
techniques with improved microstructural sensitivity for detection of subtle tissue alterations …

Gray matter abnormalities in idiopathic P arkinson's disease: Evaluation by diffusional kurtosis imaging and neurite orientation dispersion and density imaging

K Kamagata, A Zalesky, T Hatano, R Ueda… - Human brain …, 2017 - Wiley Online Library
Mapping gray matter (GM) pathology in Parkinson's disease (PD) with conventional MRI is
challenging, and the need for more sensitive brain imaging techniques is essential to …

Combined application of quantitative susceptibility mapping and diffusion kurtosis imaging techniques to investigate the effect of iron deposition on microstructural …

L Yang, Y Cheng, Y Sun, Y Xuan, J Niu… - Frontiers in aging …, 2022 - frontiersin.org
Objectives Brain iron deposition and microstructural changes in brain tissue are associated
with Parkinson's disease (PD). However, the correlation between these factors in …

Effect of dental pulp stem cells in MPTP‐induced old‐aged mice model

N Gnanasegaran, V Govindasamy… - European journal of …, 2017 - Wiley Online Library
Background Parkinson's disease (PD) is a neurodegenerative disease caused by the loss of
dopaminergic (DA‐ergic) neurons in the substantia nigra (SN) and represented as a huge …

Early and progressive microstructural brain changes in mice overexpressing human α-Synuclein detected by diffusion kurtosis imaging

A Khairnar, J Ruda-Kucerova, N Szabó… - Brain, behavior, and …, 2017 - Elsevier
Diffusion kurtosis imaging (DKI) is sensitive in detecting α-Synuclein (α-Syn) accumulation-
associated microstructural changes at late stages of the pathology in α-Syn overexpressing …

Diffusion kurtosis imaging detects the time‐dependent progress of pathological changes in the oral rotenone mouse model of Parkinson's disease

A Khairnar, J Ruda‐Kucerova, A Arab… - Journal of …, 2021 - Wiley Online Library
Clinical diagnosis of Parkinson's disease (PD) occurs typically when a substantial proportion
of dopaminergic neurons in the substantia nigra (SN) already died, and the first motor …

Diffusion tensor and restriction spectrum imaging reflect different aspects of neurodegeneration in Parkinson's disease

TR Hope, P Selnes, I Rektorová, L Anderkova… - PLoS …, 2019 - journals.plos.org
To meet the need for Parkinson's disease biomarkers and evidence for amount and
distribution of pathological changes, MRI diffusion tensor imaging (DTI) has been explored …

Diffusion kurtosis imaging detects microstructural changes in a methamphetamine-induced mouse model of Parkinson's disease

A Arab, J Ruda-Kucerova, A Minsterova… - Neurotoxicity …, 2019 - Springer
Methamphetamine (METH) abuse is known to increase the risk of Parkinson's disease (PD)
due to its dopaminergic neurotoxicity. This is the rationale for the METH model of PD …

Microstructural white matter alterations in Alzheimer's disease and amnestic mild cognitive impairment and its diagnostic value based on diffusion kurtosis imaging: a …

T Li, Y Zhang, X Fu, X Zhang, Y Luo, H Ni - Brain Imaging and Behavior, 2022 - Springer
This prospective study aimed to explore the white matter microstructural alterations in
Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI) using the Tract …