HIV‐associated chronic immune activation
M Paiardini, M Müller‐Trutwin - Immunological reviews, 2013 - Wiley Online Library
Systemic chronic immune activation is considered today as the driving force of CD 4+ T‐cell
depletion and acquired immunodeficiency syndrome (AIDS). A residual chronic immune …
depletion and acquired immunodeficiency syndrome (AIDS). A residual chronic immune …
HIV-1 pathogenesis: the virus
R Swanstrom, J Coffin - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Transmission of HIV-1 results in the establishment of a new infection, typically starting from a
single virus particle. That virion replicates to generate viremia and persistent infection in all …
single virus particle. That virion replicates to generate viremia and persistent infection in all …
Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection
Abstract HIV-1 entry into CD4+ T cells requires binding of the virus to CD4 followed by
engagement of either the CC chemokine receptor 5 (CCR5) or CXC chemokine receptor 4 …
engagement of either the CC chemokine receptor 5 (CCR5) or CXC chemokine receptor 4 …
Entry inhibitors and their use in the treatment of HIV-1 infection
AA Haqqani, JC Tilton - Antiviral research, 2013 - Elsevier
Entry of HIV into target cells is a complex, multi-stage process involving sequential
attachment and CD4 binding, coreceptor binding, and membrane fusion. HIV entry inhibitors …
attachment and CD4 binding, coreceptor binding, and membrane fusion. HIV entry inhibitors …
Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7
Sexual transmission of human immunodeficiency virus type 1 (HIV-1) most often results from
productive infection by a single transmitted/founder (T/F) virus, indicating a stringent …
productive infection by a single transmitted/founder (T/F) virus, indicating a stringent …
Chemokine receptor CCR5: from AIDS to atherosclerosis
KL Jones, JJ Maguire… - British journal of …, 2011 - Wiley Online Library
There is increasing recognition of an important contribution of chemokines and their
receptors in the pathology of atherosclerosis and related cardiovascular disease. The …
receptors in the pathology of atherosclerosis and related cardiovascular disease. The …
Coreceptors and HIV-1 pathogenesis
PR Gorry, P Ancuta - Current HIV/AIDS Reports, 2011 - Springer
The major HIV-1 coreceptors, CCR5 and CXCR4, mediate virus entry into CD4+ cells and
are therefore a critical component of the HIV-1 life cycle. Alterations in coreceptor preference …
are therefore a critical component of the HIV-1 life cycle. Alterations in coreceptor preference …
A mature macrophage is a principal HIV-1 cellular reservoir in humanized mice after treatment with long acting antiretroviral therapy
Background Despite improved clinical outcomes seen following antiretroviral therapy (ART),
resting CD4+ T cells continue to harbor latent human immunodeficiency virus type one (HIV …
resting CD4+ T cells continue to harbor latent human immunodeficiency virus type one (HIV …
Phenotypic and immunologic comparison of clade B transmitted/founder and chronic HIV-1 envelope glycoproteins
CB Wilen, NF Parrish, JM Pfaff, JM Decker… - Journal of …, 2011 - Am Soc Microbiol
Sexual transmission of human immunodeficiency virus type 1 (HIV-1) across mucosal
barriers is responsible for the vast majority of new infections. This relatively inefficient …
barriers is responsible for the vast majority of new infections. This relatively inefficient …
A maraviroc-resistant HIV-1 with narrow cross-resistance to other CCR5 antagonists depends on both N-terminal and extracellular loop domains of drug-bound CCR5
ABSTRACT CCR5 antagonists inhibit HIV entry by binding to a coreceptor and inducing
changes in the extracellular loops (ECLs) of CCR5. In this study, we analyzed viruses from …
changes in the extracellular loops (ECLs) of CCR5. In this study, we analyzed viruses from …