Cortical-subcortical interactions in goal-directed behavior

KG Cruz, YN Leow, NM Le, E Adam… - Physiological …, 2023 - journals.physiology.org
Flexibly selecting appropriate actions in response to complex, ever-changing environments
requires both cortical and subcortical regions, which are typically described as participating …

Impairments to visual disengagement in autism spectrum disorder: a review of experimental studies from infancy to adulthood

LAR Sacrey, VL Armstrong, SE Bryson… - Neuroscience & …, 2014 - Elsevier
Impairments in visual disengagement are a current focus of research in autism spectrum
disorders (ASD) and may play a key role in the early expression of social–emotional deficits …

Organization of the inputs and outputs of the mouse superior colliculus

NL Benavidez, MS Bienkowski, M Zhu… - Nature …, 2021 - nature.com
The superior colliculus (SC) receives diverse and robust cortical inputs to drive a range of
cognitive and sensorimotor behaviors. However, it remains unclear how descending cortical …

Neural circuits underlying a psychotherapeutic regimen for fear disorders

J Baek, S Lee, T Cho, SW Kim, M Kim, Y Yoon, KK Kim… - Nature, 2019 - nature.com
A psychotherapeutic regimen that uses alternating bilateral sensory stimulation (ABS) has
been used to treat post-traumatic stress disorder. However, the neural basis that underlies …

Superior colliculus bidirectionally modulates choice activity in frontal cortex

A Thomas, W Yang, C Wang, SL Tipparaju… - Nature …, 2023 - nature.com
Action selection occurs through competition between potential choice options. Neural
correlates of choice competition are observed across frontal cortex and downstream …

Control of orienting movements and locomotion by projection-defined subsets of brainstem V2a neurons

G Usseglio, E Gatier, A Heuzé, C Hérent, J Bouvier - Current Biology, 2020 - cell.com
Spatial orientation requires the execution of lateralized movements and a change in the
animal's heading in response to multiple sensory modalities. While much research has …

Cortical and subcortical contributions to short-term memory for orienting movements

CD Kopec, JC Erlich, BW Brunton, K Deisseroth… - Neuron, 2015 - cell.com
Neural activity in frontal cortical areas has been causally linked to short-term memory (STM),
but whether this activity is necessary for forming, maintaining, or reading out STM remains …

Selective optogenetic control of Purkinje cells in monkey cerebellum

Y El-Shamayleh, Y Kojima, R Soetedjo, GD Horwitz - Neuron, 2017 - cell.com
Purkinje cells of the primate cerebellum play critical but poorly understood roles in the
execution of coordinated, accurate movements. Elucidating these roles has been hampered …

Inhibitory neurons in the superior colliculus mediate selection of spatially-directed movements

J Essig, JB Hunt, G Felsen - Communications Biology, 2021 - nature.com
Decision making is a cognitive process that mediates behaviors critical for survival.
Choosing spatial targets is an experimentally-tractable form of decision making that …

Functional organisation of the mouse superior colliculus

T Wheatcroft, AB Saleem, SG Solomon - Frontiers in neural circuits, 2022 - frontiersin.org
The superior colliculus (SC) is a highly conserved area of the mammalian midbrain that is
widely implicated in the organisation and control of behaviour. SC receives input from a …