Structural and functional diversity of type IV secretion systems
Considerable progress has been made in recent years in the structural and molecular
biology of type IV secretion systems in Gram-negative bacteria. The latest advances have …
biology of type IV secretion systems in Gram-negative bacteria. The latest advances have …
Plasmids pick a bacterial partner before committing to conjugation
Bacterial conjugation was first described by Lederberg and Tatum in the 1940s following the
discovery of the F plasmid. During conjugation a plasmid is transferred unidirectionally from …
discovery of the F plasmid. During conjugation a plasmid is transferred unidirectionally from …
Cryo-electron microscopy of the f1 filamentous phage reveals insights into viral infection and assembly
Phages are viruses that infect bacteria and dominate every ecosystem on our planet. As well
as impacting microbial ecology, physiology and evolution, phages are exploited as tools in …
as impacting microbial ecology, physiology and evolution, phages are exploited as tools in …
Real-time visualisation of the intracellular dynamics of conjugative plasmid transfer
A Couturier, C Virolle, K Goldlust… - Nature …, 2023 - nature.com
Conjugation is a contact-dependent mechanism for the transfer of plasmid DNA between
bacterial cells, which contributes to the dissemination of antibiotic resistance. Here, we use …
bacterial cells, which contributes to the dissemination of antibiotic resistance. Here, we use …
Assembly mechanism of a Tad secretion system secretin-pilotin complex
The bacterial T ight ad herence S ecretion S ystem (TadSS) assembles surface pili that drive
cell adherence, biofilm formation and bacterial predation. The structure and mechanism of …
cell adherence, biofilm formation and bacterial predation. The structure and mechanism of …
DPAM: A domain parser for AlphaFold models
The recent breakthroughs in structure prediction, where methods such as AlphaFold
demonstrated near‐atomic accuracy, herald a paradigm shift in structural biology. The 200 …
demonstrated near‐atomic accuracy, herald a paradigm shift in structural biology. The 200 …
Non-antibiotic compounds associated with humans and the environment can promote horizontal transfer of antimicrobial resistance genes
I Alav, MMC Buckner - Critical Reviews in Microbiology, 2024 - Taylor & Francis
Horizontal gene transfer plays a key role in the global dissemination of antimicrobial
resistance (AMR). AMR genes are often carried on self-transmissible plasmids, which are …
resistance (AMR). AMR genes are often carried on self-transmissible plasmids, which are …
Role of the CagY antenna projection in Helicobacter pylori Cag type IV secretion system activity
SC Tran, MS McClain, TL Cover - Infection and Immunity, 2023 - Am Soc Microbiol
Helicobacter pylori strains containing the cag pathogenicity island (PAI) are associated with
the development of gastric adenocarcinoma and peptic ulcer disease. The cag PAI encodes …
the development of gastric adenocarcinoma and peptic ulcer disease. The cag PAI encodes …
The multifaceted virulence of adherent-invasive Escherichia coli
S Mansour, T Asrar, W Elhenawy - Gut Microbes, 2023 - Taylor & Francis
The surge in inflammatory bowel diseases, like Crohn's disease (CD), is alarming. While the
role of the gut microbiome in CD development is unresolved, the frequent isolation of …
role of the gut microbiome in CD development is unresolved, the frequent isolation of …
Substrate recruitment mechanism by gram-negative type III, IV, and VI bacterial injectisomes
Bacteria use a wide arsenal of macromolecular substrates (DNA and proteins) to interact
with or infect prokaryotic and eukaryotic cells. To do so, they utilize substrate-injecting …
with or infect prokaryotic and eukaryotic cells. To do so, they utilize substrate-injecting …