Autologous haematopoietic stem cell transplantation (AHSCT) is a multistep procedure that
enables destruction of the immune system and its reconstitution from haematopoietic stem …

▪ Abstract Multiple sclerosis (MS) develops in young adults with a complex predisposing
genetic trait and probably requires an inciting environmental insult such as a viral infection …

These updated EBMT guidelines review the clinical evidence, registry activity and
mechanisms of action of haematopoietic stem cell transplantation (HSCT) in multiple …

This article provides a comprehensive overview of the pathology of multiple sclerosis (MS),
including recent insights into its molecular neuropathology and immunology. It shows that all …

Background Strong immunosuppression, including chemotherapy and immune-depleting
antibodies followed by autologous haemopoietic stem-cell transplantation (aHSCT), has …

Objective: To assess in multiple sclerosis (MS) the effect of intense immunosuppression
followed by autologous hematopoietic stem cells transplantation (AHSCT) vs mitoxantrone …

In 1997, the first consensus guidelines for haematopoietic SCT (HSCT) in autoimmune
diseases (ADs) were published, while an international coordinated clinical programme was …

Objective: To summarize the evidence on immunoablative therapy followed by autologous
hematopoietic stem cell transplantation (aHSCT) to manage severe and treatment-refractory …

Clinical trials have indicated that autologous hematopoietic stem cell transplantation (HSCT)
can persistently suppress inflammatory disease activity in a subset of patients with severe …

In a recent clinical trial involving patients with metastatic melanoma, immunosuppressive
conditioning with fludarabine and cyclophosphamide resulted in a 50% response rate in …