• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

This systematic review investigated whether the insulin sensitiser metformin has a
geroprotective effect in humans. Pubmed and Embase were searched along with databases …

Although metformin has become a drug of choice for the treatment of type 2 diabetes
mellitus, some patients may not receive it owing to the risk of lactic acidosis. Metformin …

Importance Metformin is widely viewed as the best initial pharmacological option to lower
glucose concentrations in patients with type 2 diabetes mellitus. However, the drug is …

Background: Recent changes to the US Food and Drug Administration boxed warning for
metformin will increase its use in persons with historical contraindications or precautions …

Background: Sepsis is a deadly disease worldwide. Effective treatment strategy of sepsis
remains limited. There still was a controversial about association between preadmission …

Metformin, one of the oldest oral antidiabetic agents and still recommended by almost all
current guidelines as the first-line treatment for type 2 diabetes mellitus (T2DM), has become …

Metformin is an oral antihyperglycemic drug widely used to treat type 2 diabetes mellitus
(T2DM), acting via indirect activation of 5′ Adenosine monophosphate-activated Protein …

Importance Approximately 1 million patients in the United States with type 2 diabetes
mellitus and mild-to-moderate kidney disease do not receive guideline-directed therapy with …

Diabetes is accompanied by several complications. Higher prevalence of cancers,
cardiovascular diseases, chronic kidney disease (CKD), obesity, osteoporosis, and …