Effector-triggered immunity

BC Remick, MM Gaidt, RE Vance - Annual Review of …, 2023 - annualreviews.org
The innate immune system detects pathogens via germline-encoded receptors that bind to
conserved pathogen ligands called pathogen-associated molecular patterns (PAMPs). Here …

Salmonella Typhimurium and inflammation: a pathogen-centric affair

JE Galán - Nature Reviews Microbiology, 2021 - nature.com
Microbial infections are controlled by host inflammatory responses that are initiated by
innate immune receptors after recognition of conserved microbial products. As inflammation …

Salmonella Pathogenicity Island 1 (SPI-1) and Its Complex Regulatory Network

L Lou, P Zhang, R Piao, Y Wang - Frontiers in cellular and infection …, 2019 - frontiersin.org
Salmonella species can infect a diverse range of birds, reptiles, and mammals, including
humans. The type III protein secretion system (T3SS) encoded by Salmonella pathogenicity …

Regulation of small gtpases by gefs, gaps, and gdis

J Cherfils, M Zeghouf - Physiological reviews, 2013 - journals.physiology.org
Small GTPases use GDP/GTP alternation to actuate a variety of functional switches that are
pivotal for cell dynamics. The GTPase switch is turned on by GEFs, which stimulate …

Salmonellae interactions with host processes

DL LaRock, A Chaudhary, SI Miller - Nature Reviews Microbiology, 2015 - nature.com
Salmonellae invasion and intracellular replication within host cells result in a range of
diseases, including gastroenteritis, bacteraemia, enteric fever and focal infections. In recent …

Salmonella enterica serovar Typhimurium skills to succeed in the host: virulence and regulation

A Fàbrega, J Vila - Clinical microbiology reviews, 2013 - Am Soc Microbiol
Salmonella enterica serovar Typhimurium is a primary enteric pathogen infecting both
humans and animals. Infection begins with the ingestion of contaminated food or water so …

Mucosal immunity to pathogenic intestinal bacteria

A Perez-Lopez, J Behnsen, SP Nuccio… - Nature Reviews …, 2016 - nature.com
The intestinal mucosa is a particularly dynamic environment in which the host constantly
interacts with trillions of commensal microorganisms, known as the microbiota, and …

Mechanisms of phagocytosis in macrophages

A Aderem, DM Underhill - Annual review of immunology, 1999 - annualreviews.org
▪ Abstract Phagocytosis of pathogens by macrophages initiates the innate immune
response, which in turn orchestrates the adaptive response. In order to discriminate between …

Phages and the evolution of bacterial pathogens: from genomic rearrangements to lysogenic conversion

H Brüssow, C Canchaya… - … and molecular biology …, 2004 - Am Soc Microbiol
Comparative genomics demonstrated that the chromosomes from bacteria and their viruses
(bacteriophages) are coevolving. This process is most evident for bacterial pathogens where …

Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease

DR Cook, KL Rossman, CJ Der - Oncogene, 2014 - nature.com
The aberrant activity of Ras homologous (Rho) family small GTPases (20 human members)
has been implicated in cancer and other human diseases. However, in contrast to the direct …