Microglia are the resident innate immune cells in the brain with a major role in orchestrating
immune responses. They also provide a frontline of host defense in the central nervous …

Amyloid fibrils are a pathologically and functionally relevant state of protein folding, which is
generally accessible to polypeptide chains and differs fundamentally from the globular state …

Amyloid-like assembly is not only associated with pathological events, but also leads to the
development of novel nanomaterials with unique properties. Herein, using Fmoc …

Amyloid oligomers and fibrils are protein aggregates that cause an onset and progression of
many neurodegenerative diseases, diabetes type 2 and systemic amyloidosis. Although a …

The accumulation of the amyloid‐β peptides (Aβ) is central to the development of
Alzheimer's disease. The mechanism by which Aβ triggers a cascade of events that leads to …

Central to Alzheimer's disease (AD) is the assembly of the amyloid‐beta peptide (Aβ) into
fibrils. A reduction in pH accompanying inflammation or subcellular compartments, may …

Age‐related central neurodegenerative diseases, such as Alzheimer's and Parkinson's
disease, are a rising public health concern and have been plagued by repeated drug …

Amyloid Diseases involve the growth of disease specific proteins into amyloid fibrils and
their deposition in protein plaques. Amyloid fibril formation is typically preceded by …

Liquid–liquid phase separation (LLPS) compartmentalizes and concentrates
biomacromolecules into liquid-like condensates, which underlies membraneless organelles …

Amyloids share a common architecture but play disparate biological roles in processes
ranging from bacterial defense mechanisms to protein misfolding diseases. Their structures …