Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated
host response to infection. In sepsis, the immune response that is initiated by an invading …

Sepsis is a life-threatening clinical syndrome characterized by multiorgan dysfunction
caused by a dysregulated or over-reactive host response to infection. During sepsis, the …

The complement system plays a key role in pathogen immunosurveillance and tissue
homeostasis. However, subversion of its tight regulatory control can fuel a vicious cycle of …

Complement is a complex innate immune surveillance system, playing a key role in defense
against pathogens and in host homeostasis. The complement system is initiated by …

As a preformed defense system, complement faces a delicate challenge in providing an
immediate, forceful response to pathogens even at first encounter, while sparing host cells in …

Although the complement system is primarily perceived as a host defence system, a more
versatile, yet potentially more harmful side of this innate immune pathway as an …

Thrombosis is the most frequent cause of mortality worldwide and is closely linked to
haemostasis, which is the biological mechanism that stops bleeding after the injury of blood …

Nearly a century after the significance of the human complement system was recognized, we
have come to realize that its functions extend far beyond the elimination of microbes …

Development of organ dysfunction is the most important clinical event during sepsis, as it
directly relates to mortality and morbidity. Although the new definition of sepsis captures this …

Although acute or chronic inflammation is a common component of many clinical disorders,
the underlying processes can be highly distinct. In recent years, the complement system has …