Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by the
accumulation of amyloid β in the form of extracellular plaques and by intracellular …

Butyrylcholinesterase is a serine hydrolase that catalyzes the hydrolysis of esters in the
body. Unlike its sister enzyme acetylcholinesterase, butyrylcholinesterase has a broad …

Provides a timely update to a key textbook on human drug metabolism The third edition of
this comprehensive book covers basic concepts of teaching drug metabolism, starting from …

Background The mainstay of therapy for many neurodegenerative dementias still relies on
acetylcholinesterase inhibitors (AChEI); however, there is debate on various aspects of such …

Introduction Cholinergic dysfunction, demonstrated in the late 1970s and early 1980s, led to
the introduction of acetylcholinesterase inhibitors (AChEIs) in 1993 (Tacrine) to enhance …

Objective This study intends to systematically evaluate the efficacy and safety of donepezil
for improving cognitive function in patients with mild cognitive impairment (MCI), and to …

Symptomatic interventions for patients with dementia involve anti-dementia drugs to improve
cognition, psychotropic drugs for the treatment of behavioral disorders (BDs), and different …

Late-onset Alzheimer's disease (AD) is clinically characterized by a progressive decline of
memory and other cognitive functions leading to the loss of the ability to perform everyday …

Dementia is a syndrome of global and progressive deterioration of cognitive skills,
especially memory, learning, abstract thinking, and orientation, usually affecting the elderly …

Abstract Butyrylcholinesterase (BChE; EC 3.1. 1.8), an enzyme structurally related to
acetylcholinesterase, is widely distributed in the human body. It plays a role in the …