Abstract Drug-resistant TB (DR-TB) remains a significant challenge in TB treatment and
control programmes worldwide. Advances in sequencing technology have significantly …

Over the past decade, whole genome sequencing and other'omics' technologies have
defined pathogenic driver mutations to which tumor cells are addicted. Such addictions …

Multidrug-resistant tuberculosis (MDR-TB), caused by drug-resistant strains of
Mycobacterium tuberculosis, is an increasingly serious problem worldwide. Here we …

Background The results of some reports have suggested that treatment of isoniazid-resistant
tuberculosis with the recommended regimens of first-line drugs might be suboptimal. We …

Background The prognosis, specifically the case fatality and duration, of untreated
tuberculosis is important as many patients are not correctly diagnosed and therefore receive …

Current nucleic acid amplification methods to detect Mycobacterium tuberculosis are
complex, labor-intensive, and technically challenging. We developed and performed the first …

Background Treatment of multidrug resistant tuberculosis (MDR-TB) is lengthy, toxic,
expensive, and has generally poor outcomes. We undertook an individual patient data meta …

WHO Global Strategy for Containment of Antimicrobial Resistance Page 1 WHO/CDS/CSR/DRS/2001.2
DISTR: GENERAL ORIGINAL: ENGLISH WHO Global Strategy for Containment of …

Background Multidrug-resistant (MDR) tuberculosis can be acquired through de-novo
mutation during tuberculosis treatment or through transmission from other individuals with …

Drug resistance in tuberculosis (TB) is a particular problem because the lengthy therapy of
at least 6 months makes patient compliance very difficult, which frequently creates drug …