Advances in areas that include genomics, systems biology, protein structure determination
and artificial intelligence provide new opportunities for target-based antibacterial drug …

Transfer RNAs (tRNAs) play a central role in protein translation. Studying them has been
difficult in part because a simple method to simultaneously quantify their abundance and …

Highlights•RNA can be modified by diverse internal and terminal modifications.•Bacteria and
bacteriophage RNA polymerases can install RNA modifications.•Bacterial enzymes remove …

Plasmodium falciparum artemisinin (ART) resistance is driven by mutations in kelch-like
protein 13 (PfK13). Quiescence, a key aspect of resistance, may also be regulated by a yet …

Antimicrobial resistance develops as a major problem in infectious diseases treatment.
While antibiotic resistance mechanisms are usually studied using lethal antibiotic doses …

As essential components of the protein synthesis machinery, tRNAs undergo a tightly
controlled biogenesis process, which include the incorporation of numerous …

A subset of eukaryotic tRNAs is methylated in the anticodon loop, forming 3-methylcytosine
(m 3 C) modifications. In mammals, the number of tRNAs containing m 3 C modifications has …

Successful pathogens must be able to adapt to a multitude of stressors imposed by their
host. Acinetobacter baumannii has emerged as a major global health threat due to its …

Developing quantitative models of substrate specificity for RNA processing enzymes is a key
step toward understanding their biology and guiding applications in biotechnology and …

Phage viruses shape the evolution and virulence of their bacterial hosts. The Salmonella
enterica genome encodes several stress-inducible prophages. The Gifsy-1 prophage …