The MAP kinase (MAPK) signalling pathways play fundamental roles in a wide range of
cellular processes and are often deregulated in disease states. One major mode of action for …

Highlights•Protein phosphorylation controls protein activity, localization, and complex
formation.•Multivariate protein phosphorylation dynamics control cell phenotypes.• …

The behavior of gene modules in complex synthetic circuits is often unpredictable 1, 2, 3, 4.
After joining modules to create a circuit, downstream elements (such as binding sites for a …

Receptor tyrosine kinase (RTK) signaling pathways control multiple cellular decisions in
metazoans, often by regulating the expression of downstream genes. In Drosophila …

CIC and FUBP1 mutations have recently been detected in oligodendrogliomas but not in
oligoastrocytomas. However, allelic losses in the regions on chromosomal arms 19q and 1p …

The homeodomain (HD) protein Bicoid (Bcd) is thought to function as a gradient morphogen
that positions boundaries of target genes via threshold-dependent activation mechanisms …

The mitogen-activated protein kinase (MAPK) cascades transmit signals from extracellular
stimuli to a variety of distinct cellular processes. The MAPKKs in each cascade specifically …

The mitogen-activated protein kinase (MAPK) cascades are central signaling pathways that
play a central role in the regulation of most stimulated cellular processes including …

In situ hybridization (ISH) is a powerful technique for detecting nucleic acids in cells and
tissues. Here we describe three ISH procedures that are optimized for Drosophila ovaries …

Abstract The Mitogen-Activated Protein Kinase (MAPK) pathway represents one of the most
conserved signaling cascades in multicellular organisms, since its cytoplasmic components …