Hybrid molecules have become a well-established and powerful biologically relevant
heterocycles. They constitute a core structure due to their widespread use in pharmaceutical …

Tuberculosis (TB) remains a major cause of mortality worldwide, and improved treatments
are needed to combat emergence of drug resistance. Inosine 5′-monophosphate …

In the present scenario, the Synthesis of new and desired antimycobacterial agent has an
eternal demand to resist Mycobacterium tuberculosis (MTB). The design and identification of …

A series of isoniazid–amidoether derivatives was synthesized and screened for their
antimycobacterial activity in vitro and in vivo. Most of the compounds exhibited potent in vitro …

An efficient regioselective iodination of N-phenylureas was developed using iodine/
trichloroisocyanuric acid in acetonitrile at room temperature. This protocol proved to be …

Background: Griseofulvin-a mold metabolite produced by Penisilium griseofulvum is known
as an antifungal drug. Objective: Thus, the goal of this paper is the design and synthesis of …

Abstract Combretastatin A-4 (CA-4) is a well-studied and attractive molecular template to
develop new antimitotics. Several thousand of modifications were performed on the ring B …

A simple and efficient methodology for the direct halogenation of N-phenylureas was
developed using trihaloisocyanuric acids in acetonitrile at room temperature. This protocol …

Abstract Simplified 1, 3-disubstituted urea derivatives (11–24) of phenylethylamines,
homoveratylamines, 2-pyridylethylamines, 2-picolylamines as well as xylylenediamines …

Activation of chemokine CC receptors subtype 2 (CCR2) plays an important role in chronic
inflammatory processes such as atherosclerosis, multiple sclerosis and rheumatoid arthritis …