[HTML][HTML] Pre-clinical and clinical importance of miR-21 in human cancers: Tumorigenesis, therapy response, delivery approaches and targeting agents

M Hashemi, MSA Mirdamadi, Y Talebi… - Pharmacological …, 2023 - Elsevier
The field of non-coding RNA (ncRNA) has made significant progress in understanding the
pathogenesis of diseases and has broadened our knowledge towards their targeting …

Advances on natural abietane, labdane and clerodane diterpenes as anti-cancer agents: Sources and mechanisms of action

R Acquaviva, GA Malfa, MR Loizzo, J Xiao, S Bianchi… - Molecules, 2022 - mdpi.com
Extensive research over the past decades has identified numerous phytochemicals that
could represent an important source of anti-cancer compounds. There is an immediate need …

Dissecting the roles of PDCD4 in breast cancer

Q Cai, HS Yang, YC Li, J Zhu - Frontiers in Oncology, 2022 - frontiersin.org
The human programmed cell death 4 (PDCD4) gene was mapped at chromosome 10q24
and encodes the PDCD4 protein comprised of 469 amino acids. PDCD4 inhibits protein …

MicroRNAs in cancer metastasis: biological and therapeutic implications

MC Sell, CA Ramlogan-Steel, JC Steel… - Expert Reviews in …, 2023 - cambridge.org
Cancer metastasis is the primary cause of cancer-related deaths. The seeding of primary
tumours at a secondary site is a highly inefficient process requiring substantial alterations in …

[HTML][HTML] The therapeutic potential of andrographolide in cancer treatment

J Hu, Y Li, X Xie, Y Song, W Yan, Y Luo… - Biomedicine & …, 2024 - Elsevier
Cancer poses a substantial global health challenge, necessitating the widespread use of
chemotherapy and radiotherapy. Despite these efforts, issues like resistance development …

Targeting inflammation in non-small cell lung cancer through drug repurposing

T Rajasegaran, CW How, A Saud, A Ali, JCW Lim - Pharmaceuticals, 2023 - mdpi.com
Lung cancer is the most common cause of cancer-related deaths. Lung cancers can be
classified as small-cell (SCLC) or non-small cell (NSCLC). About 84% of all lung cancers …

Bone mesenchymal stem cells (BMSCs)-derived exosomal microRNA-21-5p regulates Kruppel-like factor 3 (KLF3) to promote osteoblast proliferation in vitro

M You, Z Ai, J Zeng, Y Fu, L Zhang, X Wu - Bioengineered, 2022 - Taylor & Francis
Bone mesenchymal stem cells (BMSCs)-derived exosomes (Exos) play important roles in
osteoporosis, while the regulation of microRNA (miR)-21-5p remains unclear. The BMSCs …

A novel defined PANoptosis-related miRNA signature for predicting the prognosis and immune characteristics in clear cell renal cell carcinoma: a miRNA signature for …

Y Wang, J Zhou, N Zhang, Y Zhu, Y Zhong… - International Journal of …, 2023 - mdpi.com
Clear cell renal cell carcinoma (ccRCC) is one of the most prevalent cancers, and
PANoptosis is a distinct, inflammatory-programmed cell death regulated by the …

Natural-product-derived adjunctive treatments to conventional therapy and their immunoregulatory activities in triple-negative breast cancer

LLY Kan, BCL Chan, PC Leung, CK Wong - Molecules, 2023 - mdpi.com
Triple-negative breast cancer (TNBC) is an invasive and persistent subtype of breast cancer
that is likely to be resistant to conventional treatments. The rise in immunotherapy has …

The role of different types of microRNA in the pathogenesis of breast and prostate cancer

EA Sidorova, YV Zhernov, MA Antsupova… - International Journal of …, 2023 - mdpi.com
Micro ribonucleic acids (microRNAs or miRNAs) form a distinct subtype of non-coding RNA
and are widely recognized as one of the most significant gene expression regulators in …