The provision of environmental enrichment (EE) for laboratory rats is recommended in
European guidelines governing laboratory animal welfare. It is believed the EE …

Molecular genetic studies of personality began with two high impact papers in 1996 that
showed provisional associations between the dopamine DRD4 exon III repeat region and …

Stimulant addiction is often linked to excessive risk taking, sensation seeking, and
impulsivity, but in ways that are poorly understood. We report here that a form of impulsivity …

Environmental enrichment (EE) has beneficial neurobiological, physiological and behavioral
effects. The purpose of the present paper is to review the animal research literature …

The Swiss sublines of Roman high-(RHA/Verh) and low-(RLA/Verh) avoidance rats have
been genetically selected for good vs. poor performance in two-way active avoidance since …

A disruption in normal brain development has been hypothesized to contribute to the
aetiology of major psychiatric disorders. According to the 'double-hit'hypothesis, mutant …

Environmental enrichment is a powerful way to stimulate brain and behavioral plasticity.
However the required exposure duration to reach such changes has not been substantially …

Background Rodent studies have demonstrated that adolescent social isolation results in
many behavioral perturbations, including increases in anxiety‐like behaviors. Socially …

It has been hypothesized that anxiety disorders play an important role in the initiation and
maintenance of alcohol drinking behaviors. However, the molecular mechanisms for the …

The selective breeding of Roman high-(RHA) and low-avoidance (RLA) rats for rapid vs
extremely poor acquisition of active avoidance behavior in a shuttle-box has generated two …