[HTML][HTML] Ubiquitin-mediated regulation of autophagy
RH Chen, YH Chen, TY Huang - Journal of Biomedical Science, 2019 - Springer
Autophagy is a major degradation pathway that utilizes lysosome hydrolases to degrade
cellular constituents and is often induced under cellular stress conditions to restore cell …
cellular constituents and is often induced under cellular stress conditions to restore cell …
Autophagy in health and disease: From molecular mechanisms to therapeutic target
Macroautophagy/autophagy is an evolutionally conserved catabolic process in which
cytosolic contents, such as aggregated proteins, dysfunctional organelle, or invading …
cytosolic contents, such as aggregated proteins, dysfunctional organelle, or invading …
STING directly recruits WIPI2 for autophagosome formation during STING‐induced autophagy
W Wan, C Qian, Q Wang, J Li, H Zhang, L Wang… - The EMBO …, 2023 - embopress.org
The cGAS‐STING pathway plays an important role in host defense by sensing pathogen
DNA, inducing type I IFNs, and initiating autophagy. However, the molecular mechanism of …
DNA, inducing type I IFNs, and initiating autophagy. However, the molecular mechanism of …
[HTML][HTML] The roles of ubiquitin in mediating autophagy
Ubiquitination, the post-translational modification essential for various intracellular
processes, is implicated in multiple aspects of autophagy, the major lysosome/vacuole …
processes, is implicated in multiple aspects of autophagy, the major lysosome/vacuole …
[HTML][HTML] TRABID inhibition activates cGAS/STING-mediated anti-tumor immunity through mitosis and autophagy dysregulation
YH Chen, HH Chen, WJ Wang, HY Chen… - Nature …, 2023 - nature.com
Activation of tumor-intrinsic innate immunity has been a major strategy for improving
immunotherapy. Previously, we reported an autophagy-promoting function of the …
immunotherapy. Previously, we reported an autophagy-promoting function of the …
The dialogue between the ubiquitin-proteasome system and autophagy: implications in ageing
Dysregulated proteostasis is one of the hallmarks of ageing. Damaged proteins may impair
cellular function and their accumulation may lead to tissue dysfunction and disease. This is …
cellular function and their accumulation may lead to tissue dysfunction and disease. This is …
[HTML][HTML] Platinum drugs and taxanes: can we overcome resistance?
EV Sazonova, GS Kopeina, EN Imyanitov… - Cell death …, 2021 - nature.com
Cancer therapy is aimed at the elimination of tumor cells and acts via the cessation of cell
proliferation and induction of cell death. Many research publications discussing the …
proliferation and induction of cell death. Many research publications discussing the …
[HTML][HTML] Regulation of cell cycle drivers by Cullin-RING ubiquitin ligases
The last decade has revealed new roles for Cullin-RING ubiquitin ligases (CRLs) in a myriad
of cellular processes, including cell cycle progression. In addition to CRL1, also named SCF …
of cellular processes, including cell cycle progression. In addition to CRL1, also named SCF …
[HTML][HTML] Targeting neddylation E2s: a novel therapeutic strategy in cancer
YC Zheng, YJ Guo, B Wang, C Wang… - Journal of Hematology & …, 2021 - Springer
Ubiquitin-conjugating enzyme E2 M (UBE2M) and ubiquitin-conjugating enzyme E2 F
(UBE2F) are the two NEDD8-conjugating enzymes of the neddylation pathway that take part …
(UBE2F) are the two NEDD8-conjugating enzymes of the neddylation pathway that take part …
[HTML][HTML] CDK1, the other 'master regulator'of autophagy
Autophagy and cap-dependent mRNA translation are tightly regulated by the mechanistic
target of rapamycin complex 1 (mTORC1) signalling complex in response to nutrient …
target of rapamycin complex 1 (mTORC1) signalling complex in response to nutrient …