Cellular actions of thyroid hormone may be initiated within the cell nucleus, at the plasma
membrane, in cytoplasm, and at the mitochondrion. Thyroid hormone nuclear receptors …

Abnormal chromosome content—also known as aneuploidy—is the most common
characteristic of human solid tumours. It has therefore been proposed that aneuploidy …

Pituitary adenomas are currently classified by histological, immunocytochemical and
numerous ultrastructural characteristics lacking unequivocal prognostic correlations. We …

Dopamine is a small and relatively simple molecule that fulfills diverse functions. Within the
brain, it acts as a classical neurotransmitter whose attenuation or overactivity can result in …

Abstract In March 2011, the Acromegaly Consensus Group met to revise and update the
guidelines on the diagnosis and treatment of acromegaly complications. The meeting was …

Prolactinomas account for approximately 40% of all pituitary adenomas and are an
important cause of hypogonadism and infertility. The ultimate goal of therapy for …

Pituitary adenomas are usually benign monoclonal tumours presenting either due to
hypersecretion of pituitary hormones, and/or due to local space occupying effects and …

A vertebrate securin (vSecurin) was identified on the basis of its biochemical analogy to the
Pds1p protein of budding yeast and the Cut2p protein of fission yeast. The vSecurin protein …

Human pituitary adenomas are the most common intracranial neoplasm. Typically
monoclonal in origin, a somatic mutation is a prerequisite event in tumor development. To …

The anterior pituitary gland integrates the repertoire of hormonal signals controlling thyroid,
adrenal, reproductive, and growth functions. The gland responds to complex central and …