Molecular chess? Hallmarks of anti-cancer drug resistance

IA Cree, P Charlton - BMC cancer, 2017 - Springer
Background The development of resistance is a problem shared by both classical
chemotherapy and targeted therapy. Patients may respond well at first, but relapse is …

Anti‐cancer therapies of 21st century: novel approach to treat human cancers using cold atmospheric plasma

EA Ratovitski, X Cheng, D Yan… - Plasma Processes …, 2014 - Wiley Online Library
Cold atmospheric plasma (CAP) has just recently been showing promising anti‐cancer
activities supported by ability to induce cell death via apoptosis and cell cycle arrest leading …

Anticancer activity of seaweeds

AG Gutiérrez-Rodríguez, C Juarez-Portilla… - Drug Discovery …, 2018 - Elsevier
Highlights•Anti-cancer activity of seaweeds has been probed in numerous studies.•Total
growth inhibition is a good parameter to evaluate seaweeds' activity.•We propose the …

Modulation of apoptosis by melatonin for improving cancer treatment efficiency: An updated review

K Mortezaee, M Najafi, B Farhood, A Ahmadi, Y Potes… - Life sciences, 2019 - Elsevier
Radio-and chemotherapy are the most common cancer treatment modalities. They cause
acute and late side effects on normal tissues, which is a burden for delivery of a high dose of …

Insights of crosstalk between p53 protein and the MKK3/MKK6/p38 MAPK signaling pathway in cancer

L Stramucci, A Pranteda, G Bossi - Cancers, 2018 - mdpi.com
TP53 is universally recognized as a pivotal protein in cell-cycle fate and apoptotic induction
and, unsurprisingly, it is one of the most commonly hijacked control mechanisms in cancer …

Therapeutic potential of p53 reactivation in prostate cancer: Strategies and opportunities

S Kumari, V Sharma, R Tiwari, JP Maurya… - European Journal of …, 2022 - Elsevier
Metastatic prostate cancer (mCaP) remains one of the leading causes of cancer-related
death in men worldwide. Androgen receptor (AR) drives the progression of most of the …

Potential role of p53 deregulation in modulating immune responses in human malignancies: A paradigm to develop immunotherapy

S Chauhan, S Jaiswal, V Jakhmola, B Singh… - Cancer Letters, 2024 - Elsevier
The crucial role played by the oncogenic expression of TP53, stemming from mutation or
amyloid formation, in various human malignancies has been extensively studied over the …

Induction of p53-independent apoptosis and G1 cell cycle arrest by fucoidan in HCT116 human colorectal carcinoma cells

HY Park, SH Park, JW Jeong, D Yoon, MH Han… - Marine drugs, 2017 - mdpi.com
It is well known that fucoidan, a natural sulfated polysaccharide present in various brown
algae, mediates anticancer effects through the induction of cell cycle arrest and apoptosis …

Cell fate regulation governed by p53: Friends or reversible foes in cancer therapy

B Song, P Yang, S Zhang - Cancer Communications, 2024 - Wiley Online Library
Cancer is a leading cause of death worldwide. Targeted therapies aimed at key oncogenic
driver mutations in combination with chemotherapy and radiotherapy as well as …

Recent findings on the role of wild-type and mutant p53 in cancer development and therapy

M Babamohamadi, E Babaei, B Ahmed Salih… - Frontiers in Molecular …, 2022 - frontiersin.org
The p53 protein is a tumor suppressor encoded by the TP53 gene and consists of 393
amino acids with four main functional domains. This protein responds to various cellular …