Simple Summary Hypoxia is defined as the inadequate supply of oxygen in tissues. Regions
of acute and chronic hypoxia are a universal feature of the tumor microenvironment and a …

In many cancers, tumour progression is associated with increased tissue stiffness. Yet, the
mechanisms associating tissue stiffness with tumorigenesis and malignant transformation …

Background: Mutations in the PTEN gene cause two disorders that predispose to cancer,
Bannayan–Riley–Ruvalcaba and Cowden syndromes. Some patients with a PTEN mutation …

Background ATP-binding cassette (ABC) transporters are transmembrane proteins
responsible for the efflux of a wide variety of substrates, including steroid metabolites …

2013-06-18 Assigned to THE CHINESE UNIVERSITY OF HONG KONG reassignment THE
CHINESE UNIVERSITY OF HONG KONG ASSIGNMENT OF ASSIGNORS INTEREST (SEE …

Aire is a transcriptional regulator that induces promiscuous expression of thousands of
genes encoding tissue-restricted antigens (TRAs) in medullary thymic epithelial cells …

DNA methylation provides a fundamental epigenetic mechanism to establish and promote
cell-specific gene-expression patterns, which are inherited by subsequent cell generations …

The current study examined the effects of BAX and BCL2 polymorphisms and methylation as
well as mRNA expression on susceptibility to PE. After delivery, the placentas were collected …

Survivin is a member of the apoptosis inhibitor protein family and its polymorphisms may
lead to susceptibility to cancer. The aim of this study was to investigate the possible …

Abstract Systems, methods, and apparatuses can determine and use methylation profiles of
various tissues and samples. Examples are provided. A methylation profile can be deduced …