Functional neuroimaging in psychiatry and the case for failing better
Psychiatric disorders encompass complex aberrations of cognition and affect and are
among the most debilitating and poorly understood of any medical condition. Current …
among the most debilitating and poorly understood of any medical condition. Current …
Evidence for embracing normative modeling
In this work, we expand the normative model repository introduced in Rutherford et al.,
2022a to include normative models charting lifespan trajectories of structural surface area …
2022a to include normative models charting lifespan trajectories of structural surface area …
Evaluation of brain-body health in individuals with common neuropsychiatric disorders
Importance Physical health and chronic medical comorbidities are underestimated,
inadequately treated, and often overlooked in psychiatry. A multiorgan, systemwide …
inadequately treated, and often overlooked in psychiatry. A multiorgan, systemwide …
A Systematic Evaluation of Machine Learning–Based Biomarkers for Major Depressive Disorder
Importance Biological psychiatry aims to understand mental disorders in terms of altered
neurobiological pathways. However, for one of the most prevalent and disabling mental …
neurobiological pathways. However, for one of the most prevalent and disabling mental …
Elemental psychopathology: Distilling constituent symptoms and patterns of repetition in the diagnostic criteria of the DSM-5
BackgroundThe DSM-5 features hundreds of diagnoses comprising a multitude of
symptoms, and there is considerable repetition in the symptoms among diagnoses. This …
symptoms, and there is considerable repetition in the symptoms among diagnoses. This …
The brain structure, immunometabolic and genetic mechanisms underlying the association between lifestyle and depression
Lifestyle factors have been acknowledged to be modifiable targets that can be used to
counter the increasing prevalence of depression. This study aims to investigate combining …
counter the increasing prevalence of depression. This study aims to investigate combining …
Regional, circuit and network heterogeneity of brain abnormalities in psychiatric disorders
The substantial individual heterogeneity that characterizes people with mental illness is
often ignored by classical case–control research, which relies on group mean comparisons …
often ignored by classical case–control research, which relies on group mean comparisons …
Major depressive disorder: hypothesis, mechanism, prevention and treatment
L Cui, S Li, S Wang, X Wu, Y Liu, W Yu… - … and Targeted Therapy, 2024 - nature.com
Worldwide, the incidence of major depressive disorder (MDD) is increasing annually,
resulting in greater economic and social burdens. Moreover, the pathological mechanisms …
resulting in greater economic and social burdens. Moreover, the pathological mechanisms …
Altered brain dynamic in major depressive disorder: state and trait features
Temporal neural synchrony disruption can be linked to a variety of symptoms of major
depressive disorder (MDD), including mood rigidity and the inability to break the cycle of …
depressive disorder (MDD), including mood rigidity and the inability to break the cycle of …