Immunomodulation by radiotherapy in tumour control and normal tissue toxicity

UM Cytlak, DP Dyer, J Honeychurch… - Nature Reviews …, 2022 - nature.com
Radiotherapy (RT) is a highly effective anticancer treatment that is delivered to more than
half of all patients with cancer. In addition to the well-documented direct cytotoxic effects, RT …

Radiation-induced lung injury: assessment and management

AN Hanania, W Mainwaring, YT Ghebre, NA Hanania… - Chest, 2019 - Elsevier
Radiation-induced lung injury (RILI) encompasses any lung toxicity induced by radiation
therapy (RT) and manifests acutely as radiation pneumonitis and chronically as radiation …

SBRT combined with PD-1/PD-L1 inhibitors in NSCLC treatment: a focus on the mechanisms, advances, and future challenges

Y Chen, M Gao, Z Huang, J Yu, X Meng - Journal of hematology & …, 2020 - Springer
Immune checkpoint inhibitors targeting programmed cell death 1 (PD-1), programmed cell
death ligand-1 (PD-L1), and others have shown potent clinical efficacy and have …

Immune checkpoint inhibitor therapy–related pneumonitis: patterns and management

KR Kalisz, NH Ramaiya, KR Laukamp, A Gupta - Radiographics, 2019 - pubs.rsna.org
In recent years, the use of immune checkpoint inhibitor (ICI) therapy has rapidly grown, with
increasing US Food and Drug Administration approvals of a variety of agents used as first …

Immune checkpoint inhibitor-associated pneumonitis in non-small cell lung cancer: current understanding in characteristics, diagnosis, and management

Q Zhang, L Tang, Y Zhou, W He, W Li - Frontiers in immunology, 2021 - frontiersin.org
Immunotherapy that includes programmed cell death-1 (PD-1), programmed cell death-
ligand 1 (PD-L1) and cytotoxic T lymphocyte antigen 4 (CTLA-4) inhibitors has …

Radiation therapy and PD-1/PD-L1 blockade: the clinical development of an evolving anticancer combination

J Gong, TQ Le, E Massarelli, AE Hendifar… - … for immunotherapy of …, 2018 - Springer
Several inhibitors of programmed cell death-1 (PD-1) and programmed death ligand-1 (PD-
L1) have been approved as a form of immunotherapy for multiple cancers. Ionizing radiation …

[HTML][HTML] Bronchoalveolar lavage as a diagnostic procedure: a review of known cellular and molecular findings in various lung diseases

KR Davidson, DM Ha, MI Schwarz… - Journal of thoracic …, 2020 - ncbi.nlm.nih.gov
Bronchoalveolar lavage (BAL) is a commonly used procedure in the evaluation of lung
disease as it allows for sampling of the lower respiratory tract. In many circumstances, BAL …

[HTML][HTML] The mechanism and risk factors for immune checkpoint inhibitor pneumonitis in non-small cell lung cancer patients

X Zhai, J Zhang, Y Tian, J Li, W Jing… - Cancer Biology & …, 2020 - ncbi.nlm.nih.gov
Immune checkpoint inhibitors (ICIs) are new and promising therapeutic agents for non-small
cell lung cancer (NSCLC). However, along with demonstrating remarkable efficacy, ICIs can …

Combining radiotherapy and immunotherapy in lung cancer: can we expect limitations due to altered normal tissue toxicity?

F Wirsdörfer, S De Leve, V Jendrossek - International journal of molecular …, 2018 - mdpi.com
In recent decades, technical advances in surgery and radiotherapy, as well as
breakthroughs in the knowledge on cancer biology, have helped to substantially improve the …

Radiotherapy and immunotherapy for head and neck cancer: current evidence and challenges

JM Qian, JD Schoenfeld - Frontiers in oncology, 2021 - frontiersin.org
Immune checkpoint inhibitors (ICI) have revolutionized cancer treatment over the past
decade. However, although the immune landscape suggests a strong rationale for the use of …