The genetics of addiction—a translational perspective
Addictions are serious and common psychiatric disorders, and are among the leading
contributors to preventable death. This selective review outlines and highlights the need for …
contributors to preventable death. This selective review outlines and highlights the need for …
Moderators of the association between peer and target adolescent substance use
S Marschall-Lévesque, N Castellanos-Ryan, F Vitaro… - Addictive …, 2014 - Elsevier
Associating with substance using peers is generally considered as one of the most important
predictors of adolescent substance use. However, peer association does not affect all …
predictors of adolescent substance use. However, peer association does not affect all …
Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study
E Jorgenson, KK Thai, TJ Hoffmann, LC Sakoda… - Molecular …, 2017 - nature.com
Alcohol consumption is a complex trait determined by both genetic and environmental
factors, and is correlated with the risk of alcohol use disorders. Although a small number of …
factors, and is correlated with the risk of alcohol use disorders. Although a small number of …
Drinking, smoking, and educational achievement: cross-lagged associations from adolescence to adulthood
Background Adolescent substance use is associated with lower educational achievement
but the directionality of the association remains uncertain. We analyzed data on drinking …
but the directionality of the association remains uncertain. We analyzed data on drinking …
Using polygenic scores for identifying individuals at increased risk of substance use disorders in clinical and population samples
Genome-wide, polygenic risk scores (PRS) have emerged as a useful way to characterize
genetic liability. There is growing evidence that PRS may prove useful for early identification …
genetic liability. There is growing evidence that PRS may prove useful for early identification …
ALDH2 is associated to alcohol dependence and is the major genetic determinant of “daily maximum drinks” in a GWAS study of an isolated rural chinese sample
EE Quillen, XD Chen, L Almasy, F Yang… - American Journal of …, 2014 - Wiley Online Library
Alcohol dependence (AD) is a moderately heritable phenotype with a small number of
known risk genes mapped via linkage or candidate gene studies. We considered 313 males …
known risk genes mapped via linkage or candidate gene studies. We considered 313 males …
Association of Protein Phosphatase PPM1G With Alcohol Use Disorder and Brain Activity During Behavioral Control in a Genome-Wide Methylation Analysis
B Ruggeri, C Nymberg, E Vuoksimaa… - American Journal of …, 2015 - Am Psychiatric Assoc
Objective: The genetic component of alcohol use disorder is substantial, but monozygotic
twin discordance indicates a role for nonheritable differences that could be mediated by …
twin discordance indicates a role for nonheritable differences that could be mediated by …
Adolescent alcohol use is positively associated with later depression in a population-based UK cohort
Objective: Alcohol use and internalizing problems are often positively associated during
adolescence and adulthood. However, the basis of this relationship remains poorly …
adolescence and adulthood. However, the basis of this relationship remains poorly …
Polygenic risk for alcohol dependence associates with alcohol consumption, cognitive function and social deprivation in a population‐based cohort
Alcohol dependence is frequently co‐morbid with cognitive impairment. The relationship
between these traits is complex as cognitive dysfunction may arise as a consequence of …
between these traits is complex as cognitive dysfunction may arise as a consequence of …
Polygenic contributions to alcohol use and alcohol use disorders across population-based and clinically ascertained samples
Background Studies suggest that alcohol consumption and alcohol use disorders have
distinct genetic backgrounds. Methods We examined whether polygenic risk scores (PRS) …
distinct genetic backgrounds. Methods We examined whether polygenic risk scores (PRS) …