Genome instability is a prerequisite for the development of cancer. It occurs when genome
maintenance systems fail to safeguard the genome's integrity, whether as a consequence of …

Nonalcoholic fatty liver disease (NAFLD) is a widespread hepatic disorder in the United
States and other Westernized countries. Nonalcoholic steatohepatitis (NASH), an advanced …

Precise and efficient mapping of epigenetic markers on DNA may become an important
clinical tool for prediction and identification of ailments. Methylated CpG sites are involved in …

Perfluoroalkyl acids (PFAAs) are ubiquitous and persistent environmental contaminants.
Compounds such as perfluoroocanoic acid (PFOA), perfluorooctane sulfonate (PFOS) …

There are pronounced interindividual variations in drug metabolism, drug responses, and
the incidence of adverse drug reactions. To a certain extent such variability can be …

Background The liver plays a central role in the maintenance of homeostasis and health in
general. However, there is substantial inter-individual variation in hepatic gene expression …

Long-noncoding RNAs (lncRNAs) have been shown to participate in sensitizing or de-
sensitizing cancer cells to chemical drugs during cancer therapeutics. Notably, a plethora of …

The patterns of DNA methylation in human cancer cells are highly abnormal and often
involve the acquisition of DNA hypermethylation at hundreds or thousands of CpG islands …

Background The discovery that 5-methylcytosine (5mC) can be oxidized to 5-
hydroxymethylcytosine (5hmC) by the ten-eleven translocation (TET) proteins has prompted …

Aberrant hypermethylation of CpG islands (CGI) in human tumors occurs predominantly at
repressed genes in the host tissue, but the preceding events driving this phenomenon are …