A review of recent synthetic strategies and biological activities of isoxazole
CP Pandhurnekar, HC Pandhurnekar… - Journal of …, 2023 - Wiley Online Library
Among different heterocyclic compounds, isoxazole and their analogues are very important
classes of heterocyclic compounds as they display an extensive range of biological actions …
classes of heterocyclic compounds as they display an extensive range of biological actions …
[HTML][HTML] Isoxazole/Isoxazoline skeleton in the structural modification of natural products: a review
X Wang, Q Hu, H Tang, X Pan - Pharmaceuticals, 2023 - mdpi.com
Isoxazoles and isoxazolines are five-membered heterocyclic molecules containing nitrogen
and oxygen. Isoxazole and isoxazoline are the most popular heterocyclic compounds for …
and oxygen. Isoxazole and isoxazoline are the most popular heterocyclic compounds for …
Design, synthesis, molecular modeling, DFT, ADME and biological evaluation studies of some new 1, 3, 4-oxadiazole linked benzimidazoles as anticancer agents and …
Breast cancer is the most frequent female cancer and second cause of cancer-related
deaths among women around the world. Two thirds of breast cancer patients have hormone …
deaths among women around the world. Two thirds of breast cancer patients have hormone …
Design, synthesis, in vitro anticancer and antimicrobial evaluation, SAR analysis, molecular docking and dynamic simulation of new pyrazoles, triazoles and …
HA Radwan, I Ahmad, IMM Othman… - Journal of Molecular …, 2022 - Elsevier
A new series of pyrazoles, triazoles and pyridazines based isoxazole were synthesized, and
well characterized. Their antibacterial, antifungal and cytotoxic activities were successfully …
well characterized. Their antibacterial, antifungal and cytotoxic activities were successfully …
[HTML][HTML] Synthesis of novel isoxazole–carboxamide derivatives as promising agents for melanoma and targeted nano-emulgel conjugate for improved cellular …
Background Cancer is one of the most dangerous and widespread diseases in the world
today and it has risen to the position of the leading cause of death around the globe in the …
today and it has risen to the position of the leading cause of death around the globe in the …
[HTML][HTML] Design, synthesis, X-ray crystal structures, anticancer, DNA binding, and molecular modelling studies of pyrazole–pyrazoline hybrid derivatives
We have designed and synthesized three pyrazole analogs (4, 5a, 5b), pyrazole-based
chalcones (6a–6d) and (8a–8h), and N-formyl/acetyl 1, 3, 5-trisubstituted pyrazoline analogs …
chalcones (6a–6d) and (8a–8h), and N-formyl/acetyl 1, 3, 5-trisubstituted pyrazoline analogs …
Developing Isoxazole as a Native Photo‐Cross‐Linker for Photoaffinity Labeling and Chemoproteomics
Photoaffinity labeling is a powerful technique to interrogate drug‐protein interactions in
native cellular environments. Photo‐cross‐linkers are instrumental for this technique …
native cellular environments. Photo‐cross‐linkers are instrumental for this technique …
Identification of 1, 3, 4-oxadiazoles as tubulin-targeted anticancer agents: a combined field-based 3D-QSAR, pharmacophore model-based virtual screening …
Cancer is one of the most prominent causes of death worldwide and tubulin is a crucial
protein of cytoskeleton that maintains essential cellular functions including cell division as …
protein of cytoskeleton that maintains essential cellular functions including cell division as …
[HTML][HTML] Synthesis, in-vitro inhibition of cyclooxygenases and in silico studies of new isoxazole derivatives
Isoxazole belongs to the class of five-membered heterocyclic compounds. The process of
developing new drugs has significantly gained attention due to inadequate pharmacokinetic …
developing new drugs has significantly gained attention due to inadequate pharmacokinetic …
Transition Metal‐Mediated Functionalization of Isoxazoles: A Review
Isoxazoles are an important class of heterocycles with nitrogen and oxygen in a 1, 2‐
relationship. They find wide applications in synthetic organic chemistry and are part of …
relationship. They find wide applications in synthetic organic chemistry and are part of …