The assessment of oocyte quality in human in vitro fertilization (IVF) is getting increasing
attention from embryologists. Oocyte selection and the identification of the best oocytes, in …

The ovarian follicle luteinizing hormone (LH) signaling molecules that regulate oocyte
meiotic maturation have recently been identified. The LH signal reduces preovulatory follicle …

We report studies of preimplantation human embryo development that correlate time-lapse
image analysis and gene expression profiling. By examining a large set of zygotes from in …

Oocytes undergo a range of complex processes via oogenesis, maturation, fertilization, and
early embryonic development, eventually giving rise to a fully functioning organism. To …

Context: Polycystic ovary syndrome (PCOS), the most common cause of anovulatory
infertility, is characterized by increased ovarian androgen production and arrested follicle …

The mammalian oocyte possesses powerful reprogramming factors, which can reprogram
terminally differentiated germ cells (sperm) or somatic cells within a few cell cycles. Although …

BACKGROUND The development competence of human oocytes declines with increasing
age. The objective of this study was to investigate the effect of age on gene expression …

Stem cells are defined as self-renewing cell populations that can differentiate into multiple
distinct cell types. However, hundreds of different human cell lines from embryonic, fetal and …

Gamete fusion is a critical event of mammalian fertilization. A random one-bead one-
compound combinatorial peptide library represented synthetic human egg mimics and …

Within the sperm nucleus the paternal genome remains functionally inert and protected
following protamination. This is marked by a structural morphogenesis that is heralded by a …