Diagnosis and treatment of thrombotic microangiopathy

GL Thompson, D Kavanagh - International Journal of …, 2022 - Wiley Online Library
Thrombotic microangiopathy (TMA) is characterized by thrombocytopenia, microangiopathic
haemolytic anaemia and end organ damage. TMAs have varying underlying …

[HTML][HTML] Harmonizing definitions for diagnostic criteria and prognostic assessment of transplantation-associated thrombotic microangiopathy: a report on behalf of the …

ML Schoettler, E Carreras, B Cho, CE Dandoy… - … and cellular therapy, 2023 - Elsevier
Transplantation-associated thrombotic microangiopathy (TA-TMA) is an increasingly
recognized complication of hematopoietic cell transplantation (HCT) associated with …

Hematopoietic stem cell transplantation-associated thrombotic microangiopathy and the role of advanced practice providers and pharmacists

Z Mahmoudjafari, MC Alencar, MD Alexander… - Bone Marrow …, 2023 - nature.com
Hematopoietic stem cell transplantation-associated thrombotic microangiopathy (HSCT-
TMA) is a severe and potentially life-threatening complication. HSCT-TMA is often …

A pilot trial of prophylactic defibrotide to prevent serious thrombotic microangiopathy in high‐risk pediatric patients

CS Higham, KA Shimano, A Melton… - Pediatric Blood & …, 2022 - Wiley Online Library
Background Transplant‐associated thrombotic microangiopathy (TA‐TMA) is an endothelial
injury complication of hematopoietic stem cell transplant (HSCT) leading to end‐organ …

Sickle cell disease is a risk factor for transplant-associated thrombotic microangiopathy in children

M Schoettler, E Stenger, K Spencer… - Blood …, 2023 - ashpublications.org
Transplant-associated thrombotic microangiopathy (TA-TMA) and sickle cell disease (SCD)
share features of endothelial and complement activation. Thus, we hypothesized that SCD is …

A systematic review of diagnostic, prognostic, and risk blood and urine biomarkers of transplant-associated thrombotic microangiopathy

ML Schoettler, H Bhatt, S Vasu - Frontiers in immunology, 2023 - frontiersin.org
Transplant-associated thrombotic microangiopathy (TA-TMA) is an increasingly recognized
complication of allogeneic and autologous hematopoietic cellular therapy (HCT), associated …

Treatment outcome and efficacy of therapeutic plasma exchange for transplant-associated thrombotic microangiopathy in a large real-world cohort study

LP Yang, P Zhao, YJ Wu, HX Fu, Y He, XD Mo… - Bone Marrow …, 2022 - nature.com
The efficacy and outcome of therapeutic plasma exchange (TPE) for transplant-associated
thrombotic microangiopathy (TA-TMA) remain controversial. We therefore sought to evaluate …

Use of eculizumab in children with allogeneic haematopoietic stem cell transplantation associated thrombotic microangiopathy-a multicentre retrospective PDWP and …

P Svec, R Elfeky, JE Galimard, CS Higham… - Bone Marrow …, 2023 - nature.com
Terminal complement blockade by humanised monoclonal antibody eculizumab has been
used to treat transplantation-associated thrombotic microangiopathy (TA-TMA) in recent …

Transplant-associated thrombotic microangiopathy in pediatric patients: pre-HSCT risk stratification and prophylaxis

CS Higham, G Collins, KA Shimano, A Melton… - Blood …, 2021 - ashpublications.org
Transplant-associated thrombotic microangiopathy (TA-TMA) is an endothelial injury
syndrome that complicates hematopoietic stem cell transplant (HSCT). Morbidity and …

Emerging therapeutic and preventive approaches to transplant-associated thrombotic microangiopathy

M Schoettler, S Chonat, K Williams… - Current opinion in …, 2021 - journals.lww.com
Novel therapeutic agents for TA-TMA inhibition of the complement system are under
investigation and prophylactic strategies of endothelial protection are emerging. Further …