The HIV-1 capsid, a conical shell encasing viral nucleoprotein complexes, is involved in
multiple post-entry processes during viral replication. Many host factors can directly bind to …

HIV Nef counteracts cellular host restriction factors SERINC3 and SERINC5, but our
understanding of how naturally occurring global Nef sequence diversity impacts these …

Clinical and evolutionary consequences of HIV adaptation to... : Current Opinion in HIV and
AIDS Clinical and evolutionary consequences of HIV adaptation to HLA: implications for …

HIV-1 Nef enhances virion infectivity by counteracting host restriction factor SERINC5;
however, the impact of natural Nef polymorphisms on this function is largely unknown. We …

The extensive genetic diversity of HIV-1 is a major challenge for the prevention and
treatment of HIV-1 infections. Subtype C accounts for most of the HIV-1 infections in the …

Background: With the approval of the HIV-1 capsid inhibitor, lenacapavir, capsid sequencing
will be required for managing lenacapavir-experienced individuals with detectable viremia …

Background Understanding the genetic interplay between human hosts and infectious
pathogens is crucial for how we interpret virulence factors. Here, we tested for associations …

Abstract HLA-B* 58: 01 and HLA-B* 57 are protective alleles against human
immunodeficiency virus type 1 (HIV-1) subtype B or C infection, whereas these HLA alleles …

Objective: Dolutegravir (DTG) is now a preferred component of first-line antiretroviral therapy
(ART). However, prevalence data on natural resistance to integrase inhibitors [integrase …

Amino acid preferences at a protein site depend on the role of this site in protein function
and structure as well as on external constraints. All these factors can change in the course of …