Thiazole and oxazole are compounds with a heterocyclic nucleus that have attracted the
attention of medicinal chemistry due to the great variety of biological activities that they …

Aminothiazole nuclei and their various derivatives have been long used as precursors for
the synthesis of biologically active molecules. As a typical heterocyclic amine, 2 …

The most commonly accepted hypothesis of Alzheimer's disease (AD) is the amyloid
hypothesis caused due to formation of accumulation of Aβ42 isoform, which leads to …

Increasing evidence has been published over recent years on the implication of endocrine-
disrupting chemicals (EDCs), including parabens and benzophenones in the pathogenesis …

Urease enzyme is one of the major causes of severe health issues including urinary catheter
encrustation, gastric cancer, duodenal ulcer and peptic ulcer. In search for potent anti …

The synthesis and antiproliferative effect of a series of quinoline and thiazole containing
coumarin analogs 12a-d and 13a-f respectively, on mice leukemic cells was performed. The …

A series of potential biological active substituted thiadiazoles 5a-j and oxadiazoles 6a-j were
obtained via a multistep synthesis sequence with a simple and convenient approach by …

A great extent of nitrogen containing heterocyclic moiety comprising sulfur atom is
recognized as a valuable combination of therapeutics in medicinal chemistry. In particular …

Hypoxia is a feature of all solid tumours, contributing to tumour progression. Activation of HIF-
1α plays a critical role in promoting tumour angiogenesis and metastasis. Since its …

New series of hydrazones 5–18 were synthesized, in good yields, by reacting 4-methyl-2-(4-
(trifluoromethyl) phenyl) thiazole-5-carbohydrazide with differently substituted …