The methods for the culture and cardiomyocyte differentiation of human embryonic stem
cells, and later human induced pluripotent stem cells (hiPSC), have moved from a complex …

The call for a paradigm change in toxicology from the United States National Research
Council in 2007 initiates awareness for the invention and use of human‐relevant alternative …

The immature phenotype of human pluripotent stem cell derived cardiomyocytes (hPSC-
CMs) constrains their potential in cell therapy and drug testing. In this study, we report that …

Transfer RNAs are essential for translating genetic information into proteins. The human
genome contains hundreds of predicted tRNA genes, many in multiple copies. How their …

Pluripotent stem cell-derived cardiomyocytes (CMs) have great potential in the development
of new therapies for cardiovascular disease. In particular, human induced pluripotent stem …

Human induced pluripotent stem cells (hiPSCs) represent an almost limitless source of cells
for disease modelling and drug screening applications. Here we established an efficient and …

Wnt signaling is a key regulator of vertebrate heart development; however, specific roles for
human cardiomyocyte development remain uncertain. Here we use human embryonic stem …

Billions of US dollars are invested every year by the pharmaceutical industry in drug
development, with the aim of introducing new drugs that are effective and have minimal side …

Cardiac induction requires stepwise integration of BMP and WNT pathway activity. Human
embryonic stem cells (hESCs) are developmentally and clinically relevant for studying the …

Heart failure is a major public health problem affecting over 23 million people worldwide. In
this study, we present the results of a large scale meta-analysis of heart failure GWAS and …