▪ Abstract Synaptic transmission is a dynamic process. Postsynaptic responses wax and
wane as presynaptic activity evolves. This prominent characteristic of chemical synaptic …

Muscle fatigue is an exercise-induced reduction in maximal voluntary muscle force. It may
arise not only because of peripheral changes at the level of the muscle, but also because …

Different types of synapses are specialized to interpret spike trains in their own way by virtue
of the complement of short-term synaptic plasticity mechanisms they possess. Numerous …

Abstract α-Synuclein (α-Syn) is a 14 kDa protein of unknown function that has been
implicated in the pathophysiology of Parkinson's disease (PD). Here, we show that α-Syn …

Vesicle exocytosis releases content to mediate many biological events, including synaptic
transmission essential for brain functions. Following exocytosis, endocytosis is initiated to …

Pain after nerve damage is an expression of pathological operation of the nervous system,,
one hallmark of which is tactile allodynia—pain hypersensitivity evoked by innocuous …

The intracellular calcium concentration ([Ca 2+]) has important roles in the triggering of
neurotransmitter release and the regulation of short-term plasticity (STP). Transmitter …

The quantal release of glutamate depends on its transport into synaptic vesicles. Recent
work has shown that a protein previously implicated in the uptake of inorganic phosphate …

Taking a step-by-step approach to modelling neurons and neural circuitry, this textbook
teaches students how to use computational techniques to understand the nervous system at …

Brief depolarization of cerebellar Purkinje cells was found to inhibit parallel fiber and
climbing fiber EPSCs for tens of seconds. This depolarization-induced suppression of …