The clinical manifestation of neurodegenerative diseases is initiated by the selective
alteration in the functionality of distinct neuronal populations. The pathology of many …

The unfolded protein response (UPR) is a homeostatic mechanism by which cells regulate
levels of misfolded proteins in the endoplasmic reticulum (ER). Although it is well …

The endoplasmic reticulum (ER) is a dynamic intracellular organelle with multiple functions
essential for cellular homeostasis, development, and stress responsiveness. In response to …

The common underlying feature of most neurodegenerative diseases such as Alzheimer
disease (AD), prion diseases, Parkinson disease (PD), and amyotrophic lateral sclerosis …

Persistent endoplasmic reticulum (ER) stress is thought to drive the pathology of many
chronic disorders due to its potential to elicit aberrant inflammatory signaling and facilitate …

In eukaryotic cells, the endoplasmic reticulum (ER) is the cell compartment involved in
secretory protein translocation and quality control of secretory protein folding. Different …

The maintenance and regulation of proteostasis is a critical function for post-mitotic neurons
and its dysregulation is increasingly implicated in neurodegenerative diseases. Despite …

Astrocytes are glial cells that support neurological function in the central nervous system
(CNS), in part, by providing structural support for neuronal synapses and blood vessels …

Prion diseases are fatal neurodegenerative disorders affecting several mammalian species,
characterized by the accumulation of the misfolded form of the prion protein, which is …

Neurodegenerative diseases are inseparably linked with aging and increase as life
expectancy extends. There are common dysfunctions in various cellular events shared …