Animal models of mechanisms of SARS‐CoV‐2 infection and COVID‐19 pathology

SJ Cleary, SC Pitchford, RT Amison… - British journal of …, 2020 - Wiley Online Library
The coronavirus disease 2019 (COVID‐19) pandemic caused by SARS‐CoV‐2 infections
has led to a substantial unmet need for treatments, many of which will require testing in …

[HTML][HTML] In vitro and in vivo models for studying SARS-CoV-2, the etiological agent responsible for COVID-19 pandemic

RB Rosa, WM Dantas, JCF do Nascimento… - Viruses, 2021 - mdpi.com
The emergence and rapid worldwide spread of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has prompted the scientific community to rapidly develop in …

Planning experiments: Updated guidance on experimental design and analysis and their reporting III

MJ Curtis, SPH Alexander, G Cirino… - British Journal of …, 2022 - Wiley Online Library
Scientists who plan to publish in British Journal of Pharmacology (BJP) must read this article
before undertaking a study. This editorial provides guidance for the design of experiments …

[HTML][HTML] ARRIVE 2.0 and the British Journal of Pharmacology: Updated guidance for 2020

E Lilley, SC Stanford, DE Kendall… - British journal of …, 2020 - ncbi.nlm.nih.gov
1. BACKGROUND The BJP has been and remains an active advocate of the ARRIVE
(Animal Research: Reporting of in vivo Experiments) guidelines (Kilkenny, Browne, Cuthill …

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

N Percie du Sert, V Hurst, A Ahluwalia… - Journal of Cerebral …, 2020 - journals.sagepub.com
Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal
Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve …

[HTML][HTML] Best Practice in the chemical characterisation of extracts used in pharmacological and toxicological research—The ConPhyMP—Guidelines12

M Heinrich, B Jalil, M Abdel-Tawab… - Frontiers in …, 2022 - frontiersin.org
Background: Research on medicinal plants and extracts derived from them differs from
studies performed with single compounds. Extracts obtained from plants, algae, fungi …

A practical guide for transparent reporting of research on natural products in the British Journal of Pharmacology: Reproducibility of natural product research

AA Izzo, M Teixeira, SPH Alexander… - British Journal of …, 2020 - Wiley Online Library
Natural products continue to be an important source of medicines and drug templates.
Indeed, it has been estimated that approximately a third of all Food and Drug Administration …

Gut Akkermansia muciniphila ameliorates metabolic dysfunction-associated fatty liver disease by regulating the metabolism of L-aspartate via gut-liver axis

Y Rao, Z Kuang, C Li, S Guo, Y Xu, D Zhao, Y Hu… - Gut …, 2021 - Taylor & Francis
The gut bacterium Akkermansia muciniphila has been increasingly recognized for its
therapeutic potential in treating metabolic disorders, including obesity, diabetes, and …

Quercetin induces p53‐independent cancer cell death through lysosome activation by the transcription factor EB and reactive oxygen species‐dependent ferroptosis

ZX Wang, J Ma, XY Li, Y Wu, H Shi… - British journal of …, 2021 - Wiley Online Library
Background and Purpose Cancer cells exhibit more dependence on iron and enhanced
sensitivity to iron‐dependent, programmed cell death (ferroptosis) than normal cells …

Small-molecule inhibitors of the coronavirus spike: ACE2 protein–protein interaction as blockers of viral attachment and entry for SARS-CoV-2

D Bojadzic, O Alcazar, J Chen, ST Chuang… - ACS infectious …, 2021 - ACS Publications
Inhibitors of the protein–protein interaction (PPI) between the SARS-CoV-2 spike protein
and human ACE2 (hACE2), which acts as a ligand–receptor pair that initiates the viral …