The world demand for animal-based food products is anticipated to increase by 70% by
2050. Meeting this demand in a way that has a minimal impact on the environment will …

Climate change imposes a severe threat to agricultural systems, food security, and human
nutrition. Meanwhile, efforts in crop and livestock gene editing have been undertaken to …

The relative ease, speed, and biological scope of clustered regularly interspaced short
palindromic repeats (CRISPR)/CRISPR-associated Protein9 (Cas9)-based reagents for …

Targeted nucleases have provided researchers with the ability to manipulate virtually any
genomic sequence, enabling the facile creation of isogenic cell lines and animal models for …

Abstract Background The CRISPR-Cas9 system is a widely utilized platform for transgenic
animal production in various species, although its off-target effects should be addressed …

The ability to efficiently inactivate or replace genes in model organisms allowed a rapid
expansion of our understanding of many of the genetic, biochemical, molecular and cellular …

One of the most powerful strategies to investigate biology we have as scientists, is the ability
to transfer genetic material in a controlled and deliberate manner between organisms. When …

Genetic improvement of cattle around the globe has been, and will continue to be, an
important driver of animal agriculture sustainability. There are several reproductive and …

Studies to evaluate the therapeutic potential of stem cells in humans would benefit from
more realistic animal models. In veterinary medicine, companion animals naturally develop …

Aberrant epigenetic reprogramming often results in developmental defects in somatic cell
nuclear transfer (SCNT) embryos during embryonic genome activation (EGA). Bovine eight …