The chromatin response to double-strand DNA breaks and their repair
Cellular DNA is constantly being damaged by numerous internal and external mutagenic
factors. Probably the most severe type of insults DNA could suffer are the double-strand …
factors. Probably the most severe type of insults DNA could suffer are the double-strand …
Histone acetylation dynamics in repair of DNA double-strand breaks
S Aricthota, PP Rana, D Haldar - Frontiers in Genetics, 2022 - frontiersin.org
Packaging of eukaryotic genome into chromatin is a major obstacle to cells encountering
DNA damage caused by external or internal agents. For maintaining genomic integrity, the …
DNA damage caused by external or internal agents. For maintaining genomic integrity, the …
The endogenous retrovirus-derived long noncoding RNA TROJAN promotes triple-negative breast cancer progression via ZMYND8 degradation
X Jin, XE Xu, YZ Jiang, YR Liu, W Sun, YJ Guo… - Science …, 2019 - science.org
Human endogenous retroviruses (HERVs) play pivotal roles in the development of breast
cancer. However, the detailed mechanisms of noncoding HERVs remain elusive. Here, our …
cancer. However, the detailed mechanisms of noncoding HERVs remain elusive. Here, our …
Non-canonical DNA/RNA structures during transcription-coupled double-strand break repair: roadblocks or bona fide repair intermediates?
Although long overlooked, it is now well understood that DNA does not systematically
assemble into a canonical double helix, known as B-DNA, throughout the entire genome but …
assemble into a canonical double helix, known as B-DNA, throughout the entire genome but …
WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks
P Caron, T Pankotai, WW Wiegant… - Genes & …, 2019 - genesdev.cshlp.org
DNA double-strand breaks (DSBs) at RNA polymerase II (RNAPII) transcribed genes lead to
inhibition of transcription. The DNA-dependent protein kinase (DNA-PK) complex plays a …
inhibition of transcription. The DNA-dependent protein kinase (DNA-PK) complex plays a …
Preserving genome integrity and function: the DNA damage response and histone modifications
Modulation of chromatin templates in response to cellular cues, including DNA damage,
relies heavily on the post-translation modification of histones. Numerous types of histone …
relies heavily on the post-translation modification of histones. Numerous types of histone …
[HTML][HTML] DNA double-strand break repair: Putting zinc fingers on the sore spot
JK Singh, H van Attikum - Seminars in Cell & Developmental Biology, 2021 - Elsevier
Abstract Zinc-Finger (ZnF) proteins represent one of the most abundant group of proteins in
the human genome. At first characterized as DNA binding proteins, it has become …
the human genome. At first characterized as DNA binding proteins, it has become …
Poly (ADP-ribose) binding and macroH2A mediate recruitment and functions of KDM5A at DNA lesions
The histone demethylase KDM5A erases histone H3 lysine 4 methylation, which is involved
in transcription and DNA damage responses (DDRs). While DDR functions of KDM5A have …
in transcription and DNA damage responses (DDRs). While DDR functions of KDM5A have …
Oncoprotein-specific molecular interaction maps (SigMaps) for cancer network analyses
Tumor-specific elucidation of physical and functional oncoprotein interactions could improve
tumorigenic mechanism characterization and therapeutic response prediction. Current …
tumorigenic mechanism characterization and therapeutic response prediction. Current …
Regulation of ZMYND8 to treat cancer
Y Chen, YH Tsai, SH Tseng - Molecules, 2021 - mdpi.com
Zinc finger myeloid, nervy, and deformed epidermal autoregulatory factor 1-type containing
8 (Zinc finger MYND-type containing 8, ZMYND8) is a transcription factor, a histone H3 …
8 (Zinc finger MYND-type containing 8, ZMYND8) is a transcription factor, a histone H3 …