ABSTRACT MAPK families play an important role in complex cellular programs like
proliferation, differentiation, development, transformation, and apoptosis. At least three …

Mammalian oocytes go through a long and complex developmental process while acquiring
the competencies that are required for fertilization and embryogenesis. Recent advances in …

The transmission of extracellular signals into their intracellular targets is mediated by a
network of interacting proteins that regulate a large number of cellular processes …

Widmann, Christian, Spencer Gibson, Matthew B. Jarpe, and Gary L. Johnson. Mitogen-
Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human …

Publisher Summary The chapter introduces the mitogen-activated protein (MAP) kinase
(MAPK) module. The identification of MAP kinase pathways exemplifies the power of …

Microtubules are dynamic polymers that play crucial roles in a large number of cellular
functions. Their pivotal role in mitosis makes them a target for the development of anticancer …

The anticancer agent paclitaxel (Taxol®) stabilizes tubulin polymerization resulting in arrest
in mitosis and apoptotic cell death. Normal human fibroblasts depleted of functional p53 by …

The mitogen-activated protein kinase (MAPK) cascade is one of the most important of the
intracellular signaling pathways that play a crucial role in cell proliferation, cell differentiation …

Specific mRNA degradation mediated by double-stranded RNA (dsRNA), which is termed
RNA interference (RNAi), is a useful tool with which to study gene function in several …

Mitogen-activated protein kinase (MAPK) is a family of Ser/Thr protein kinases that are
widely distributed in eukaryotic cells. Studies in the last decade revealed that MAPK …