Diverse therapeutic developments for post-traumatic stress disorder (PTSD) indicate common mechanisms of memory modulation
Post-traumatic stress disorder (PTSD), characterized by abnormally persistent and
distressing memories, is a chronic debilitating condition in need of new treatment options …
distressing memories, is a chronic debilitating condition in need of new treatment options …
The Aversive Lens: Stress effects on the prefrontal-cingulate cortical pathways that regulate emotion
Abstract ARNSTEN, AFT, MKP Joyce and AC Roberts. The Aversive Lens: Stress effects on
the prefrontal-cingulate cortical pathways that regulate emotion. NEUROSCI BIOBEHAV …
the prefrontal-cingulate cortical pathways that regulate emotion. NEUROSCI BIOBEHAV …
Viewpoints: Approaches to defining and investigating fear
There is disagreement on how best to define and investigate fear. Nature Neuroscience
asked Dean Mobbs to lead experts from the fields of human and animal affective …
asked Dean Mobbs to lead experts from the fields of human and animal affective …
Stress-driven potentiation of lateral hypothalamic synapses onto ventral tegmental area dopamine neurons causes increased consumption of palatable food
LE Linders, L Patrikiou, M Soiza-Reilly… - Nature …, 2022 - nature.com
Stress can cause overconsumption of palatable high caloric food. Despite the important role
of stress eating in obesity and (binge) eating disorders, its underlying neural mechanisms …
of stress eating in obesity and (binge) eating disorders, its underlying neural mechanisms …
Chronic unpredictable mild stress-induced behavioral changes are coupled with dopaminergic hyperfunction and serotonergic hypofunction in mouse models of …
Q Lu, A Mouri, Y Yang, K Kunisawa… - Behavioural Brain …, 2019 - Elsevier
Accumulating evidence shows that stressful events evoke molecular alterations in the brain,
considered a pathology in major depressive disorder (MDD). However, the abnormalities of …
considered a pathology in major depressive disorder (MDD). However, the abnormalities of …
Dopamine in fear extinction
XI Salinas-Hernández, S Duvarci - Frontiers in synaptic neuroscience, 2021 - frontiersin.org
The ability to extinguish fear memories when threats are no longer present is critical for
adaptive behavior. Fear extinction represents a new learning process that eventually leads …
adaptive behavior. Fear extinction represents a new learning process that eventually leads …
Fast and slow: Recording neuromodulator dynamics across both transient and chronic time scales
P Ma, P Chen, EI Tilden, S Aggarwal, A Oldenborg… - Science …, 2024 - science.org
Neuromodulators transform animal behaviors. Recent research has demonstrated the
importance of both sustained and transient change in neuromodulators, likely due to tonic …
importance of both sustained and transient change in neuromodulators, likely due to tonic …
Mixed selectivity: Cellular computations for complexity
The property of mixed selectivity has been discussed at a computational level and offers a
strategy to maximize computational power by adding versatility to the functional role of each …
strategy to maximize computational power by adding versatility to the functional role of each …
A facile aptamer-based sensing strategy for dopamine detection through the fluorescence energy transfer between dye and single-wall carbon nanohorns
J Zhang, S Hou, J Zhang, N Liang, L Zhao - Spectrochimica Acta Part A …, 2022 - Elsevier
Dopamine (DBA) as an important biomarker, plays a crucial role in disease diagnosis. In this
study, we have developed a fast and simple aptamer-based fluorescence strategy which …
study, we have developed a fast and simple aptamer-based fluorescence strategy which …
Mesolimbic dopamine projections mediate cue-motivated reward seeking but not reward retrieval in rats
Efficient foraging requires an ability to coordinate discrete reward-seeking and reward-
retrieval behaviors. We used pathway-specific chemogenetic inhibition to investigate how …
retrieval behaviors. We used pathway-specific chemogenetic inhibition to investigate how …