Diverse therapeutic developments for post-traumatic stress disorder (PTSD) indicate common mechanisms of memory modulation

SB Raut, PA Marathe, L van Eijk, R Eri… - Pharmacology & …, 2022 - Elsevier
Post-traumatic stress disorder (PTSD), characterized by abnormally persistent and
distressing memories, is a chronic debilitating condition in need of new treatment options …

The Aversive Lens: Stress effects on the prefrontal-cingulate cortical pathways that regulate emotion

AFT Arnsten, MKP Joyce, AC Roberts - Neuroscience & Biobehavioral …, 2023 - Elsevier
Abstract ARNSTEN, AFT, MKP Joyce and AC Roberts. The Aversive Lens: Stress effects on
the prefrontal-cingulate cortical pathways that regulate emotion. NEUROSCI BIOBEHAV …

Viewpoints: Approaches to defining and investigating fear

D Mobbs, R Adolphs, MS Fanselow, LF Barrett… - Nature …, 2019 - nature.com
There is disagreement on how best to define and investigate fear. Nature Neuroscience
asked Dean Mobbs to lead experts from the fields of human and animal affective …

Stress-driven potentiation of lateral hypothalamic synapses onto ventral tegmental area dopamine neurons causes increased consumption of palatable food

LE Linders, L Patrikiou, M Soiza-Reilly… - Nature …, 2022 - nature.com
Stress can cause overconsumption of palatable high caloric food. Despite the important role
of stress eating in obesity and (binge) eating disorders, its underlying neural mechanisms …

Chronic unpredictable mild stress-induced behavioral changes are coupled with dopaminergic hyperfunction and serotonergic hypofunction in mouse models of …

Q Lu, A Mouri, Y Yang, K Kunisawa… - Behavioural Brain …, 2019 - Elsevier
Accumulating evidence shows that stressful events evoke molecular alterations in the brain,
considered a pathology in major depressive disorder (MDD). However, the abnormalities of …

Dopamine in fear extinction

XI Salinas-Hernández, S Duvarci - Frontiers in synaptic neuroscience, 2021 - frontiersin.org
The ability to extinguish fear memories when threats are no longer present is critical for
adaptive behavior. Fear extinction represents a new learning process that eventually leads …

Fast and slow: Recording neuromodulator dynamics across both transient and chronic time scales

P Ma, P Chen, EI Tilden, S Aggarwal, A Oldenborg… - Science …, 2024 - science.org
Neuromodulators transform animal behaviors. Recent research has demonstrated the
importance of both sustained and transient change in neuromodulators, likely due to tonic …

Mixed selectivity: Cellular computations for complexity

KM Tye, EK Miller, FH Taschbach, MK Benna, M Rigotti… - Neuron, 2024 - cell.com
The property of mixed selectivity has been discussed at a computational level and offers a
strategy to maximize computational power by adding versatility to the functional role of each …

A facile aptamer-based sensing strategy for dopamine detection through the fluorescence energy transfer between dye and single-wall carbon nanohorns

J Zhang, S Hou, J Zhang, N Liang, L Zhao - Spectrochimica Acta Part A …, 2022 - Elsevier
Dopamine (DBA) as an important biomarker, plays a crucial role in disease diagnosis. In this
study, we have developed a fast and simple aptamer-based fluorescence strategy which …

Mesolimbic dopamine projections mediate cue-motivated reward seeking but not reward retrieval in rats

B Halbout, AT Marshall, A Azimi, M Liljeholm… - Elife, 2019 - elifesciences.org
Efficient foraging requires an ability to coordinate discrete reward-seeking and reward-
retrieval behaviors. We used pathway-specific chemogenetic inhibition to investigate how …