Multiple sclerosis (MS) is a central nervous system (CNS) disorder, which is mediated by an
abnormal immune response coordinated by T and B cells resulting in areas of inflammation …

Hematopoietic stem cells (HSCs) are the earliest cells of the immune system, giving rise to B
and T lymphocytes, monocytes, tissue macrophages, and dendritic cells. In animal models …

These updated EBMT guidelines review the clinical evidence, registry activity and
mechanisms of action of haematopoietic stem cell transplantation (HSCT) in multiple …

Clinical trials have indicated that autologous hematopoietic stem cell transplantation (HSCT)
can persistently suppress inflammatory disease activity in a subset of patients with severe …

Background Alemtuzumab is a lymphocyte depleting monoclonal antibody that has
demonstrated superior efficacy over interferon β-1a for relapsing–remitting multiple sclerosis …

Abstract Rationale Phase I/II studies of autologous hematopoietic stem cell transplantation
(HSCT) for multiple sclerosis (MS) were initiated, based on results of experimental …

Objective To investigate the results of real-world application of non-myeloablative
autologous HSCT for multiple sclerosis (MS). Methods Between July 2003 and October …

Over the last decade, hematopoietic stem cells transplantation (HSCT) has been
increasingly used in the treatment of severe progressive autoimmune diseases. We report a …

There were 21 patients with rapidly progressive multiple sclerosis (MS) treated on a phase
1/2 study of intense immune suppressive therapy and autologous hematopoietic stem cell …

Multiple sclerosis, systemic lupus erythematosus, and rheumatoid arthritis are immune-
mediated diseases that are responsive to suppression or modulation of the immune system …