Narcolepsy is a rare brain disorder that reflects a selective loss or dysfunction of orexin (also
known as hypocretin) neurons of the lateral hypothalamus. Narcolepsy type 1 (NT1) is …

Fifty years since the first description of an association between HLA and human disease,
HLA molecules have proven to be central to physiology, protective immunity and …

Abstract Narcolepsy type 1 (NT1) is a chronic sleep disorder resulting from the loss of a
small population of hypothalamic neurons that produce wake-promoting hypocretin (HCRT; …

Narcolepsy is the most common neurological cause of chronic sleepiness. The discovery
about 20 years ago that narcolepsy is caused by selective loss of the neurons producing …

Narcolepsy is a chronic sleep disorder that has a typical onset in adolescence and is
characterized by excessive daytime sleepiness, which can have severe consequences for …

Background Evaluation and interpretation of the literature on obstructive sleep apnea (OSA)
allows for consolidation and determination of the key factors important for clinical …

We take for granted the ability to fall asleep or to snap out of sleep into wakefulness, but
these changes in behavioral state require specific switching mechanisms in the brain that …

The aim of this European initiative is to facilitate a structured discussion to improve the next
edition of the International Classification of Sleep Disorders (ICSD), particularly the chapter …

We carried out a genome-wide association study of IgA nephropathy, a major cause of
kidney failure worldwide. We studied 1,194 cases and 902 controls of Chinese Han …

Type 1 narcolepsy (T1N) is caused by hypocretin/orexin (HCRT) neuronal loss. Association
with the HLA DQB1* 06: 02/DQA1* 01: 02 (98% vs. 25%) heterodimer (DQ0602), T cell …